effect of piperonyl butoxide on pyrethroid-resistance-associated esterases in Helicoverpa armigera (Hubner) (Lepidoptera: Noctuidae)

Pyrethroid resistance in field populations of Australian Helicoverpa armigera (Hubner) is primarily a consequence of the overproduction of esterase isoenzymes which metabolise and sequester pyrethroid insecticides. Biochemical studies have shown that pyrethroid-resistance-associated esterases in H a...

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Bibliographic Details
Published in:Pest management science 2005-04, Vol.61 (4), p.397-401
Main Authors: Young, S.J, Gunning, R.V, Moores, G.D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical control
Control
cotton
Drug Synergism
Effects
enzyme activity
enzyme inhibitors
Enzymes
esterases
Esterases - antagonists & inhibitors
Esterases - metabolism
Fundamental and applied biological sciences. Psychology
Gossypium hirsutum
Helicoverpa armigera
insect control
insect pests
Insecticide Resistance
Insecticides
Insecticides - pharmacology
Insects
Isoenzymes - metabolism
Larva - enzymology
Moths - enzymology
pesticide synergists
Phytopathology. Animal pests. Plant and forest protection
piperonyl butoxide
Piperonyl Butoxide - pharmacology
plant pests
Protozoa. Invertebrates
Pyrethrins - pharmacology
pyrethroid insecticides
pyrethroids
resistance
Time Factors
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Summary:Pyrethroid resistance in field populations of Australian Helicoverpa armigera (Hubner) is primarily a consequence of the overproduction of esterase isoenzymes which metabolise and sequester pyrethroid insecticides. Biochemical studies have shown that pyrethroid-resistance-associated esterases in H armigera are inhibited by the insecticide synergist piperonyl butoxide (PBO). Esterase inhibition by PBO did not occur immediately after dosing, but exhibited maximum inhibition 3-4 h after dosage. Esterase activity subsequently recovered until full activity was restored by 24 h. Topical bioassays using a pre-treatment of PBO showed that maximum H armigera mortality was achieved with pre-treatment times corresponding to maximum esterase inhibition. These results demonstrated that, with correct temporal application, PBO can restore pyrethroid efficacy against H armigera. It would also be expected that restoration of efficacy with other conventional insecticides, currently compromised by esterase-based resistance mechanisms, would occur.
ISSN:1526-498X
1526-4998
DOI:10.1002/ps.996