Prevalence of theCYP2D610 (C100T), 4 (G1846A), and 14 (G1758A) alleles among Iranians of different ethnicities

The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Here, we compared the prevalence of the CYP2D6*10, *4, and 14* alleles in an Iranian population of different ethnicities with those of other p...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2015-01, Vol.9, p.2627
Main Authors: Bagheri, Ali, Kamalidehghan, Behnam, Haghshenas, Maryam, Azadfar, Parisa, Akbari, Leila, Mohammad Hossein Sangtarash, Vejdandoust, Faramarz, Ahmadipour, Fatemeh, Goh, Yong Meng, Houshmand, Massoud
Format: Article
Language:English
Subjects:
Alleles
Asian people
Biology
Breast cancer
Cancer therapies
Clinical trials
Conformation
Consent
Consortia
CYP2D6 protein
Cytochrome
Cytochrome P450
Deoxyribonucleic acid
DNA
DNA sequencing
Drug therapy
Drugs
Enzymes
Ethnicity
Females
Gene frequency
Gene polymorphism
Genetic counseling
Genetic engineering
Genotype & phenotype
Males
Medical research
Metabolism
Minority & ethnic groups
Mitochondrial DNA
Pharmacology
Phenotypes
Polymerase chain reaction
Polymorphism
Population
Population genetics
Populations
Predictions
Restriction fragment length polymorphism
Side effects
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Summary:The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Here, we compared the prevalence of the CYP2D6*10, *4, and 14* alleles in an Iranian population of different ethnicities with those of other populations. Allele and genotype frequency distributions of CYP2D6*10 variants and predicted phenotypes including extensive metabolizers, intermediate metabolizers, and poor metabolizers were analysed in blood samples of 300 unrelated healthy individuals in an Iranian population using polymerase chain reaction (PCR)-restriction fragment length polymorphism, PCR-single-strand conformation polymorphism, and direct genomic DNA sequencing. The CYP2D6*4 (G1846A) and *14 (G1758A) allelic frequencies were not detected in different ethnicities, demonstrating the absence of a significant contribution of these alleles in Iranian populations. However, the T/T, C/T, and C/C genotype frequencies of the CYP2D6*10 allele were significantly different (P
ISSN:1177-8881
DOI:10.2147/DDDT.S79709