Synthesis of graphene/carbon nanofiber for electrochemical determination of levodopa in the presence of uric acid

• Published in: Ionics 2019-06, Vol.25 (6), p.2835-2843
• Main Authors: Wang, Wan Qiu, Yue, Hong Yan, Yu, Ze Min, Huang, Shuo, Song, Shan Shan, Gao, Xin, Guan, En Hao, Zhang, Hong Jie, Wang, Zhao
• Format: Article
• Language: English
• Subjects: Carbon fibers; Chemical vapor deposition; Chemistry; Chemistry and Materials Science; Condensed Matter Physics; Electrochemistry; Electrodes; Electroless plating; Energy Storage; Graphene; Morphology; Nanofibers; Nickel; Optical and Electronic Materials; Organic chemistry; Original Paper; Raman spectroscopy; Renewable and Green Energy; Reproducibility; Scanning electron microscopy; Selectivity; Uric acid; Urine; Voltammetry
• ISSN: 0947-7047; 1862-0760
• DOI: 10.1007/s11581-018-2801-2

Carbon nanofiber (CNF) was prepared by electrospinning using polypropylene and nickel was coated on the CNF by electroless plating. Then, graphene (Gr) was synthesized on the surface of nickel by chemical vapor deposition. After etching nickel, the Gr/CNF was obtained eventually and then used as a working electrode for the determination of levodopa in the presence of uric acid by cyclic voltammetry and differential pulse voltammetry. The morphology and structure were investigated by scanning electron microscopy and Raman spectroscopy, respectively. The results indicate that the electrode exhibits a high sensitivity of 0.26 μA·μM −1 and a low measured limit of detection of 1 μM for levodopa in the range of 1–60 μM. The electrode shows excellent selectivity, reproducibility, and stability. It was also applied to determine levodopa in the spiked human urine samples.