Hepatoprotective effects of sea buckthorn (Hippophae rhamnoides L.) against carbon tetrachioride induced liver injury in rats

Liver injuries induced by carbon tetrachioride are the best-characterized system of xenobiotic-induced hepatotoxicity and commonly used model for the screening of hepatoprotective activities of drugs. The present study evaluates the hepatoprotective activity of sea buckthorn (Hippophae rhamnoides L....

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2008-07, Vol.88 (9), p.1592
Main Authors: Geetha, Suryakumar, Jayamurthy, Purushothaman, Pal, Karan, Pandey, Shweta, Kumar, Ratan, Sawhney, RC
Format: Article
Language:English
Subjects:
Antioxidants
Effects
Flowers & plants
Liver diseases
Rodents
Studies
Toxicity
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Summary:Liver injuries induced by carbon tetrachioride are the best-characterized system of xenobiotic-induced hepatotoxicity and commonly used model for the screening of hepatoprotective activities of drugs. The present study evaluates the hepatoprotective activity of sea buckthorn (Hippophae rhamnoides L.), family Elaeagnaceae, on carbon tetrachloride (...)-induced liver injury in male albino rats. The study was performed on Sprague-Dawley male albino rats weighing about 180-200 g. The animals were pretreated with three different doses of leaf extract (50, 100 and 200 mg kg... body weight) for 5 days. Hepatotoxicity was induced by single oral administration of 1.5 mL ... kg... body weight on the fifth day. The animals were then sacrificed and assessed for various biochemical parameters. Administration of ... significantly enhanced glutamate oxaloacetate transferase (GOT), glutamate pyruvate transferase (GPT), alkaline phosphatase (ALP) and bilirubin, and decreased total protein levels in the serum. Treatment with ... also significantly decreased reduced glutathione (GSH), and decreased glutathione peroxidase and superoxide dismutase activity. ... treatment also caused a significant increase in hepatic lipid peroxidation as assessed by malondialdehyde (MDA) levels in the tissue. Pretreatment of leaf extract at a concentration of 100 and 200 mg kg... body weight significantly (P < 0.05) protected the animals from ...-induced liver injury. The extract significantly restricted the ...-induced increase of GOT, GPT, ALP and bilirubin and better maintained protein levels in the serum. Further, it also enhanced GSH and decreased MDA levels. The results show that sea buckthorn leaf extract has significant hepatoprotective effects which might be due to its antioxidant activity and can be developed as a nutraceutical or food supplement against liver diseases. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0022-5142
1097-0010