The Prins Reaction in the Fragrance Industry: 100th Anniversary (1919–2019)

The Prins reaction, an acid‐catalyzed condensation of alkenes with aldehydes, is used extensively in the fragrance industry. This year we celebrate the 100th anniversary of the discovery of this reaction. In honor of this occasion we present an overview of the diverse applications of the Prins react...

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Bibliographic Details
Published in:Angewandte Chemie 2019-05, Vol.131 (22), p.7248-7253
Main Authors: Doro, Franco, Akeroyd, Niels, Schiet, Franc, Narula, Anubhav
Format: Article
Language:English
Subjects:
Aldehyde
Aldehydes
Alkene
Alkenes
Chemical synthesis
Chemistry
Cosmetics industry
Duftstoffe
Flavor
Kondensationsreaktionen
Perfumes
Prins-Reaktion
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Summary:The Prins reaction, an acid‐catalyzed condensation of alkenes with aldehydes, is used extensively in the fragrance industry. This year we celebrate the 100th anniversary of the discovery of this reaction. In honor of this occasion we present an overview of the diverse applications of the Prins reaction in the synthesis of flavor and fragrance ingredients. To pay tribute to the inventor of the Prins reaction, Hendrik Jacobus Prins, we also provide some insight into his life, scientific, and entrepreneurial accomplishments. Duftes Jubiläum: Die Prins‐Reaktion wurde 1919 von Hendrik Jacobus Prins bei Forschungen zur Synthese neuer Duftstoffe entdeckt und fand anschließend breite Anwendung in der Naturstoffsynthese. Dieser Essay über Riechstoffkomponenten, die durch die Prins‐Reaktion synthetisiert werden, feiert das 100‐jährige Jubiläum der Entdeckung der Reaktion.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201814470