The prediction of liver disease status using Doppler observations of the hepatic and portal venous system compared with liver biopsy in patients with chronic hepatitis C

Objective: To investigate the influence of chronic hepatitis C-induced hepatic tissue damage on hepatic dopplerographic hemodynamics. Subjects and methods: A total of 118 patients with chronic hepatitis C underwent both liver biopsy and ultrasound with duplex dopplerography of right hepatic and port...

Full description

Saved in:
Bibliographic Details
Published in:Research and Reports in Focused Ultrasound 2014-10, Vol.2, p.1
Main Authors: Zytoon, Ashraf Anas, Gad Allah, Abdel Naser A., Faisal, Ahmed
Format: Article
Language:English
Subjects:
Family medical history
Flow velocity
Heart
Hepatitis
Hepatitis C
Hepatology
Hypertension
Infections
Internal medicine
Laboratories
Liver cirrhosis
Liver diseases
Ultrasonic imaging
Veins & arteries
Visualization
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To investigate the influence of chronic hepatitis C-induced hepatic tissue damage on hepatic dopplerographic hemodynamics. Subjects and methods: A total of 118 patients with chronic hepatitis C underwent both liver biopsy and ultrasound with duplex dopplerography of right hepatic and portal veins. A liver biopsy was performed during sonography, and biopsy specimens were evaluated. Hepatic and portal vein flow pattern was correlated with the total modified histologic activity index (HAI), fibrosis score, and intrahepatic fat content. Hepatic vein Doppler curve was evaluated. The flow of the portal vein was characterized according to the velocity undulation. Multiple logistic regression analysis was used to identify the best histological features that might contribute to hepatic hemodynamic alterations. Results: The Doppler sonography spectrum of the right hepatic vein was classified as triphasic in 27 (23%), biphasic in 67 (57%), and monophasic in 24 (20%) patients. A significant difference was observed in the HAI, fibrosis score, and hepatosteatosis between patients with triphasic, biphasic, and monophasic flow patterns in the right hepatic vein (P
ISSN:2253-2609
2253-2609
DOI:10.2147/RRFU.S57202