Standardization of dual time point [18F] 2-Deoxy-2-fluoro-D-glucose-positron emission tomography performed with different positron emission tomography scanners using partial volume correction

• Published in: Research and reports in nuclear medicine 2015-01, Vol.5, p.1
• Main Authors: Mikasa, Shohei, Akamatsu, Go, Taniguchi, Takafumi, Kidera, Daisuke, Kihara, Ken, Matsuoka, Kohki, Amakusa, Shinji, Yoshida, Tsuyoshi, Sasaki, Masayuki
• Format: Article
• Language: English
• Subjects: Accuracy; Breast cancer; Evaluation; Glucose; Lung cancer; Lymphatic system; Medical imaging; Metastasis; Patients; PET imaging; Practice guidelines (Medicine); Scanners; Standardization; Studies; Tomography; Tumors
• ISSN: 2230-228X; 2230-228X
• DOI: 10.2147/RRNM.S73413

Introduction: The aim of this study was to examine the possibility of using the partial volume correction (PVC) to standardize dual time point [18F] 2-Deoxy-2-fluoro-D-glucose (FDG)-positron emission tomography (PET) studies with two PET scanners. Materials and methods: One hundred and thirteen lesions from 96 breast cancer patients were examined. FDG-PET scans were performed at both 60 and 120 minutes after FDG injection using different PET scanners. The maximum standardized uptake values ([SUV.sub.max]s) were measured at both time points ([SUV.sub.max]1 and [SUV.sub.max]2) and the percent change in the [SUV.sub.max] (Δ%[SUV.sub.max]) between the two time points was calculated. PVC was performed using a look-up table generated based on the recovery coefficient curves and point spread function of each scanner. Results: The [SUV.sub.max]1, the [SUV.sub.max]2, and the Δ%[SUV.sub.max] were 5.67 ± 4.45, 5.15 ± 4.29, and -9.30% ± 20.54%, respectively. After PVC, all parameters significantly increased to 10.44 ± 5.55, 10.23 ± 5.77, and -1.15% ± 21.66%, respectively. In addition, the number of lesions with a positive Δ%[SUV.sub.max] increased after PVC, from 26.5% to 40.7%. Conclusion: PVC of the [SUV.sub.max] is considered to be useful for standardizing dual time point FDG-PET studies in patients with breast cancer performed using different PET scanners. This method is also expected to be useful for standardizing multicenter PET studies. Keywords: FDG-PET, SUV, standardization, partial volume correction, breast cancer, dual time point imaging