HLA-C12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug reactions

• Published in: The pharmacogenomics journal 2019-06, Vol.19 (3), p.277-285
• Main Authors: Yan, Sijia, Xiong, Hao, Shao, Fengmin, Zhang, Wen, Yang, Fanping, Qi, Zheng, Chen, Shengan, He, Lin, Jiang, Menglin, Su, Yu, Zhu, Huizhong, Qin, Shengying, Zhu, Qinyuan, Luo, Xiaoqun, Xing, Qinghe
• Format: Article
• Language: English
• Subjects: 45; 45/77; 631/208/212/1728; 692/53/2423; Adult; Adverse and side effects; Aged; Aged, 80 and over; Alleles; Antigens; Asians - genetics; Biomedical and Life Sciences; Biomedicine; Cardiovascular disease; Carrier frequencies; Cerebrovascular diseases; Dermatology; Drug Eruptions - genetics; Drug-Related Side Effects and Adverse Reactions - genetics; Drugs; Drugs, Chinese Herbal - adverse effects; Erythema; Female; Gene Expression; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genotype; Histocompatibility antigen HLA; HLA-C Antigens - genetics; Hospitals; Human Genetics; Humans; Intravenous administration; Male; Membrane proteins; Middle Aged; Oncology; Pathogenicity; Pathogens; Patients; Pharmacotherapy; Population; Population genetics; Psychopharmacology; Risk factors; Saponins - adverse effects; Side effects; Urticaria; Values; Vascular diseases; Young Adult
• ISSN: 1470-269X; 1473-1150
• DOI: 10.1038/s41397-018-0051-3

Xuesaitong (XST) is mainly used to treat cardiovascular and cerebrovascular diseases, sometimes causing cutaneous adverse drug reactions (cADRs) with unknown mechanisms of pathogenicity or risk factors. We aimed to verify whether human leukocyte antigen ( HLA ) alleles are associated with XST-related cADRs in Han Chinese population. We carried out an association study including 12 subjects with XST-induced cADRs, 283 controls, and 28 XST-tolerant subjects. Five out of 12 patients with XST-induced cADRs carried HLA-C*12:02 , and all of them received XST via intravenous drip. The carrier frequency of HLA-C*12:02 was significantly high compare to that of the control population (Pc = 4.4 × 10 −4 , odds ratio (OR) = 21.75, 95% CI = 5.78–81.88). Compared with that of the XST-tolerant group, the patients who received XST through intravenous drip presented a higher OR of cADRs (Pc = 0.011, OR = 27.00, 95% CI = 2.58–282.98). The results suggest that HLA-C*12:02 is a potentially predictive marker of XST-induced cADRs in Han Chinese, especially when XST is administered via intravenous drip.