Hormone receptor status and survival of medullary breast cancer patients

Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC betw...

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Bibliographic Details
Published in:Saudi medical journal 2017-02, Vol.38 (2), p.156-162
Main Authors: Aksoy Asude, Odabas Hatice, Kaya Serap, Bozkurt Oktay, Degirmenci Mustafa, Topcu, Turkan O, Aytekin Aydın, Arpaci Erkan, Avci Nilufer, Pilanci, Kezban N, Cinkir, Havva Y, Bozkaya Yakup, Yalcin, Cirak, Gumus Mahmut
Format: Article
Language:English
Subjects:
Breast cancer
Clinical outcomes
Demographics
Histopathology
Hormones
Medical prognosis
Progesterone
Survivor
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Summary:Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2017.2.18055