Hormone receptor status and survival of medullary breast cancer patients

Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC betw...

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Published in:Saudi medical journal 2017-02, Vol.38 (2), p.156-162
Main Authors: Aksoy Asude, Odabas Hatice, Kaya Serap, Bozkurt Oktay, Degirmenci Mustafa, Topcu, Turkan O, Aytekin Aydın, Arpaci Erkan, Avci Nilufer, Pilanci, Kezban N, Cinkir, Havva Y, Bozkaya Yakup, Yalcin, Cirak, Gumus Mahmut
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Language:English
Subjects:
Breast cancer
Clinical outcomes
Demographics
Histopathology
Hormones
Medical prognosis
Progesterone
Survivor
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container_end_page 162
container_issue 2
container_start_page 156
container_title Saudi medical journal
container_volume 38
creator Aksoy Asude
Odabas Hatice
Kaya Serap
Bozkurt Oktay
Degirmenci Mustafa
Topcu, Turkan O
Aytekin Aydın
Arpaci Erkan
Avci Nilufer
Pilanci, Kezban N
Cinkir, Havva Y
Bozkaya Yakup
Yalcin, Cirak
Gumus Mahmut
description Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p
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Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p&lt;0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p&lt;0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p&gt;0.05). Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.</description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>DOI: 10.15537/smj.2017.2.18055</identifier><language>eng</language><publisher>Riyadh: Prince Sultan Military Medical City (PSMMC)</publisher><subject>Breast cancer ; Clinical outcomes ; Demographics ; Histopathology ; Hormones ; Medical prognosis ; Progesterone ; Survivor</subject><ispartof>Saudi medical journal, 2017-02, Vol.38 (2), p.156-162</ispartof><rights>Saudi Medical Journal 2017. This work is licensed under the Creative Commons Attribution – Non-Commercial – Share Alike License http://creativecommons.org/licenses/by-nc-sa/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c161t-32cc7faf00de296316c6be0813f9e16777cb148176f45955b6edaea476110d353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2229281077/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2229281077?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590,75126</link.rule.ids></links><search><creatorcontrib>Aksoy Asude</creatorcontrib><creatorcontrib>Odabas Hatice</creatorcontrib><creatorcontrib>Kaya Serap</creatorcontrib><creatorcontrib>Bozkurt Oktay</creatorcontrib><creatorcontrib>Degirmenci Mustafa</creatorcontrib><creatorcontrib>Topcu, Turkan O</creatorcontrib><creatorcontrib>Aytekin Aydın</creatorcontrib><creatorcontrib>Arpaci Erkan</creatorcontrib><creatorcontrib>Avci Nilufer</creatorcontrib><creatorcontrib>Pilanci, Kezban N</creatorcontrib><creatorcontrib>Cinkir, Havva Y</creatorcontrib><creatorcontrib>Bozkaya Yakup</creatorcontrib><creatorcontrib>Yalcin, Cirak</creatorcontrib><creatorcontrib>Gumus Mahmut</creatorcontrib><title>Hormone receptor status and survival of medullary breast cancer patients</title><title>Saudi medical journal</title><description>Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). 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subjects Breast cancer
Clinical outcomes
Demographics
Histopathology
Hormones
Medical prognosis
Progesterone
Survivor
title Hormone receptor status and survival of medullary breast cancer patients
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