Thermal Lens Microscope and Microchip Chemistry

Thermal lens spectrometry was realized under an optical microscope by controlling the chromatic aberration of the objective lens system. This thermal lens microscope (TLM) is ultrasensitive to non-fluorescent molecules and detection at even the yoctomole level in a liquid was confirmed. The TLM is w...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2019-02, Vol.92 (2), p.469-473
Main Author: Kitamori, Takehiko
Format: Article
Language:English
Subjects:
Aberration
Analytical chemistry
Blood vessels
Chemical reactions
Chip formation
Chips
Continuous flow
Fluorescence
Glass substrates
Microchannels
Microfluidics
Optical microscopes
Organic chemistry
Scientific imaging
Selectivity
Spectrometry
Spectrophotometry
Spectroscopy
Thermal lensing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thermal lens spectrometry was realized under an optical microscope by controlling the chromatic aberration of the objective lens system. This thermal lens microscope (TLM) is ultrasensitive to non-fluorescent molecules and detection at even the yoctomole level in a liquid was confirmed. The TLM is widely applicable, almost the same as spectrophotometry, but its specificity for the analyte species is similarly poor. During development of the TLM equipment, a microchannel fabricated on a glass substrate was used as a sample vessel, which then became a microchemical chip. The generalized microchemical chip design method, micro unit operation (MUO) and continuous flow chemical processing (CFCP) was proposed and a variety of complex chemical processes for analyses, syntheses, and biomedical experiments could be integrated onto the microchemical chip. Therefore, the development of microchemical chips realized significant expansion of the field of microfluidics. Microchemical chips are also suitable devices for separation chemistry, and combination of the TLM and microchemical chips could compensate for the poor selectivity of TLM. These innovative methods will not only impact analytical chemistry but also microfluidics and most certainly other research fields such as biology and medicine. This account of The Chemical Society of Japan Award for Creative Work 2006 introduces these achievements.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20180276