Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction

A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin an...

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Bibliographic Details
Published in:Biotechnology, biotechnological equipment biotechnological equipment, 2017-01, Vol.31 (1), p.182-186
Main Authors: Franco-Molina, Moises A., Mendoza-Gamboa, Edgar, Coronado-Cerda, Erika E., Zarate-Triviño, Diana, Arizpe-Coronado, Juan E., Zapata-Benavides, Pablo, Ramos Zayas, Yareellys, Tamez-Guerra, Reyes, Rodríguez-Padilla, Cristina
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Clinical trials
cytokine
Cytokines
Flow cytometry
Ibuprofen
IMMUNEPOTENT CRP
Inflammation
Interleukin 10
Interleukin 2
Interleukin 4
Interleukin 6
Nonsteroidal anti-inflammatory drugs
Saliva
Surgery
Tumor necrosis factor-α
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Summary:A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin and Laskin, and the analysis of cytokine production (IL-2, IL-4, IL-6, IL-10, TNF-α, INF-γ) in saliva was done by flow cytometry. The swelling process after surgery was significant (p < 0.05) and the treatments with IMMUNEPOTENT CRP or ibuprofen controlled this process properly; no difference between the groups was found (p < 0.05). Both treatments were shown to modulate the cytokine production. These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice.
ISSN:1310-2818
1314-3530
DOI:10.1080/13102818.2016.1249408