Asymmetric Lewis acid-catalyzed 1,3-dipolar cycloadditions

Highly tuned, one-point binding chiral iron and ruthenium complexes selectively coordinate and activate α,β-unsaturated aldehydes and ketones toward asymmetric catalytic Diels-Alder cycloaddition reactions. Here we focus on the application of these transition-metal Lewis acids to asymmetric catalyti...

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Bibliographic Details
Published in:Pure and applied chemistry 2008-05, Vol.80 (5), p.1013-1018
Main Authors: Bădoiu, Andrei, Brinkmann, Yasmin, Viton, Florian, Kündig, E. Peter
Format: Article
Language:English
Subjects:
1,3-dipolar cycloadditions
Aldehydes
Aromatic compounds
asymmetric reactions
Asymmetry
Catalysis
Coordination compounds
Cycloaddition
Isoxazolidines
Ketones
Lewis acid
Lewis acids
nitrile oxides
nitrones
Ruthenium compounds
Transition metals
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Summary:Highly tuned, one-point binding chiral iron and ruthenium complexes selectively coordinate and activate α,β-unsaturated aldehydes and ketones toward asymmetric catalytic Diels-Alder cycloaddition reactions. Here we focus on the application of these transition-metal Lewis acids to asymmetric catalytic 1,3-dipolar cycloaddition reaction between enals and cyclic and acyclic nitrones as well as aryl nitrile oxides to give isoxazolidines and isoxazolines, respectively.
ISSN:0033-4545
1365-3075
DOI:10.1351/pac200880051013