Functionalized main-group organometallics for organic synthesis

Highly functionalized Grignard-reagents can be easily obtained by an iodine­magnesim exchange reaction and further reacted with various electrophiles. Via a B­Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synth...

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Bibliographic Details
Published in:Pure and applied chemistry 2002-01, Vol.74 (1), p.11-17
Main Authors: Knochel, Paul, Hupe, Eike, Dohle, Wolfgang, Lindsay, David M., Bonnet, Véronique, Quéguiner, Guy, Boudier, Andreas, Kopp, Felix, Demay, Stéphane, Seidel, Naka, Calaza, M. Isabel, Vu, Viet Anh, Sapountzis, Ioannis, Bunlaksananusorn, Tanasri
Format: Article
Language:English
Subjects:
Exchanging
Iodine
Organometallic compounds
Reagents
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Summary:Highly functionalized Grignard-reagents can be easily obtained by an iodine­magnesim exchange reaction and further reacted with various electrophiles. Via a B­Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.
ISSN:0033-4545
1365-3075
DOI:10.1351/pac200274010011