Economic drug discovery and rational medicinal chemistry for tropical diseases

In order to fulfill research objectives around target-based drug discovery in the field of anti-infective agents that are prevalent mainly in poor Third World countries, selection of biological and chemical targets is guided by economic drug discovery and rational medicinal chemistry. Selection of b...

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Bibliographic Details
Published in:Pure and applied chemistry 2005-11, Vol.77 (11), p.1957-1964
Main Author: Chibale, Kelly
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
enzyme inhibitors
Malaria
medicinal chemistry
Natural products
Organic chemistry
Pharmaceutical sciences
R&D
Reductases
Research & development
Scaffolds
trypanosomiasis
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Summary:In order to fulfill research objectives around target-based drug discovery in the field of anti-infective agents that are prevalent mainly in poor Third World countries, selection of biological and chemical targets is guided by economic drug discovery and rational medicinal chemistry. Selection of biological targets of therapeutic relevance in multiple disease-causing organisms, as well as the use of natural products and existing drugs as chemical scaffolds for the discovery and design of novel therapeutics should be viable strategies underpinning drug discovery research in poor Third World countries. In this regard, biological targets of interest to our program include disulfide reductases and cysteine proteases (CPs), while chemical scaffolds include existing antimalarial agents and natural products.
ISSN:0033-4545
1365-3075
DOI:10.1351/pac200577111957