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Growth Stimulation Effects of Environmentally Realistic Contaminant Mixtures on a Marine Diatom
To estimate mixture effects caused by the high number of chemicals simultaneously present in the environment, methods for routine effect assessment of environmentally realistic contaminant mixtures are needed. We repeatedly exposed the marine diatom Phaeodactylum tricornutum to SpeediskTM passive sa...
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| Published in: | Environmental toxicology and chemistry 2019-06, Vol.38 (6), p.1313-1322 |
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| cites | cdi_FETCH-LOGICAL-c3861-c5543bbde9c8ae914b0bc4879c39f102b725f7d64b5c7d37428a7d03bd2a5ff63 |
| container_end_page | 1322 |
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| container_title | Environmental toxicology and chemistry |
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| creator | Moeris, Samuel Vanryckeghem, Francis Demeestere, Kristof Huysman, Steve Vanhaecke, Lynn Schamphelaere, Karel A.C. |
| description | To estimate mixture effects caused by the high number of chemicals simultaneously present in the environment, methods for routine effect assessment of environmentally realistic contaminant mixtures are needed. We repeatedly exposed the marine diatom Phaeodactylum tricornutum to SpeediskTM passive sampler extracts and observed statistically significant growth stimulation up to 6 and 7% for samples from inside and outside the harbor of Zeebrugge, respectively. These effects were found at summed contaminant concentrations (159–166 ng L–1) that were within a 1.1‐ to 2.4‐fold range of those observed in grab water samples taken during sampler deployment. These stimulatory effects were confirmed in 2 independent tests with extracts stored for |
| doi_str_mv | 10.1002/etc.4431 |
| format | article |
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We repeatedly exposed the marine diatom Phaeodactylum tricornutum to SpeediskTM passive sampler extracts and observed statistically significant growth stimulation up to 6 and 7% for samples from inside and outside the harbor of Zeebrugge, respectively. These effects were found at summed contaminant concentrations (159–166 ng L–1) that were within a 1.1‐ to 2.4‐fold range of those observed in grab water samples taken during sampler deployment. These stimulatory effects were confirmed in 2 independent tests with extracts stored for <1 or 8 mo that had undergone limited sample handling, whereas no effects were observed for extracts that had been stored for 16 mo that had undergone repeated handling (notably repeated freezing and thawing) before biotest spiking. Targeted analysis by ultra‐high performance liquid chromatography was performed to quantify 88 personal care products (n = 8), pesticides (n = 28), and pharmaceuticals (n = 52). Among these compounds, multivariate statistical analysis put forward the β‐blocker atenolol as explaining most of the observed variation in mixture composition between the growth‐stimulating and no effect–causing extracts. However, when tested individually over the entire concentration range present in the extracts, atenolol did not have any effect on P. tricornutum, suggesting that nontargeted substances in the extracts may have contributed to the observed stimulatory effects. Nevertheless, the present study shows that exposure to contaminant mixtures at environmentally realistic concentrations can lead to small but significant growth stimulation effects on the marine diatom P. tricornutum. Environ Toxicol Chem 2019;38:1313–1322. © 2019 SETAC</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.4431</identifier><identifier>PMID: 30924961</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aquatic Organisms - drug effects ; Aquatic Organisms - growth & development ; Atenolol ; Consumer products ; Contaminants ; Diatoms - drug effects ; Diatoms - growth & development ; Discriminant Analysis ; Ecotoxicology ; Environmental assessment ; Environmental effects ; Environmental Monitoring ; Freeze-thaw ; Freezing ; Growth stimulation ; Harbors ; High performance liquid chromatography ; Least-Squares Analysis ; Liquid chromatography ; Marine pollution ; Mixture toxicology ; Multivariate Analysis ; Multivariate statistical analysis ; Organic chemistry ; Passive sampler ; Pesticides ; Principal Component Analysis ; Realistic contaminant mixtures ; Statistical analysis ; Statistical methods ; Stimulation ; Thawing ; Water analysis ; Water Pollutants, Chemical - toxicity ; Water sampling</subject><ispartof>Environmental toxicology and chemistry, 2019-06, Vol.38 (6), p.1313-1322</ispartof><rights>2019 SETAC</rights><rights>2019 SETAC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3861-c5543bbde9c8ae914b0bc4879c39f102b725f7d64b5c7d37428a7d03bd2a5ff63</citedby><cites>FETCH-LOGICAL-c3861-c5543bbde9c8ae914b0bc4879c39f102b725f7d64b5c7d37428a7d03bd2a5ff63</cites><orcidid>0000-0002-2596-1807 ; 0000-0002-5063-922X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30924961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moeris, Samuel</creatorcontrib><creatorcontrib>Vanryckeghem, Francis</creatorcontrib><creatorcontrib>Demeestere, Kristof</creatorcontrib><creatorcontrib>Huysman, Steve</creatorcontrib><creatorcontrib>Vanhaecke, Lynn</creatorcontrib><creatorcontrib>Schamphelaere, Karel A.C.</creatorcontrib><title>Growth Stimulation Effects of Environmentally Realistic Contaminant Mixtures on a Marine Diatom</title><title>Environmental toxicology and chemistry</title><addtitle>Environ Toxicol Chem</addtitle><description>To estimate mixture effects caused by the high number of chemicals simultaneously present in the environment, methods for routine effect assessment of environmentally realistic contaminant mixtures are needed. We repeatedly exposed the marine diatom Phaeodactylum tricornutum to SpeediskTM passive sampler extracts and observed statistically significant growth stimulation up to 6 and 7% for samples from inside and outside the harbor of Zeebrugge, respectively. These effects were found at summed contaminant concentrations (159–166 ng L–1) that were within a 1.1‐ to 2.4‐fold range of those observed in grab water samples taken during sampler deployment. These stimulatory effects were confirmed in 2 independent tests with extracts stored for <1 or 8 mo that had undergone limited sample handling, whereas no effects were observed for extracts that had been stored for 16 mo that had undergone repeated handling (notably repeated freezing and thawing) before biotest spiking. Targeted analysis by ultra‐high performance liquid chromatography was performed to quantify 88 personal care products (n = 8), pesticides (n = 28), and pharmaceuticals (n = 52). Among these compounds, multivariate statistical analysis put forward the β‐blocker atenolol as explaining most of the observed variation in mixture composition between the growth‐stimulating and no effect–causing extracts. However, when tested individually over the entire concentration range present in the extracts, atenolol did not have any effect on P. tricornutum, suggesting that nontargeted substances in the extracts may have contributed to the observed stimulatory effects. Nevertheless, the present study shows that exposure to contaminant mixtures at environmentally realistic concentrations can lead to small but significant growth stimulation effects on the marine diatom P. tricornutum. 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Among these compounds, multivariate statistical analysis put forward the β‐blocker atenolol as explaining most of the observed variation in mixture composition between the growth‐stimulating and no effect–causing extracts. However, when tested individually over the entire concentration range present in the extracts, atenolol did not have any effect on P. tricornutum, suggesting that nontargeted substances in the extracts may have contributed to the observed stimulatory effects. Nevertheless, the present study shows that exposure to contaminant mixtures at environmentally realistic concentrations can lead to small but significant growth stimulation effects on the marine diatom P. tricornutum. 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| ispartof | Environmental toxicology and chemistry, 2019-06, Vol.38 (6), p.1313-1322 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aquatic Organisms - drug effects Aquatic Organisms - growth & development Atenolol Consumer products Contaminants Diatoms - drug effects Diatoms - growth & development Discriminant Analysis Ecotoxicology Environmental assessment Environmental effects Environmental Monitoring Freeze-thaw Freezing Growth stimulation Harbors High performance liquid chromatography Least-Squares Analysis Liquid chromatography Marine pollution Mixture toxicology Multivariate Analysis Multivariate statistical analysis Organic chemistry Passive sampler Pesticides Principal Component Analysis Realistic contaminant mixtures Statistical analysis Statistical methods Stimulation Thawing Water analysis Water Pollutants, Chemical - toxicity Water sampling |
| title | Growth Stimulation Effects of Environmentally Realistic Contaminant Mixtures on a Marine Diatom |
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