Cooperativity transitions driven by higher-order oligomer formations in ligand-induced receptor dimerization

While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via minimal representations of physical observables, effects arising from higher-order oligomer (e.g., trimer and tetramer) formations of unobserved receptors have received less attention. He...

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Bibliographic Details
Published in:arXiv.org 2019-12
Main Authors: Watabe, Masaki, Arjunan, Satya N V, Wei Xiang Chew, Kaizu, Kazunari, Takahashi, Koichi
Format: Article
Language:English
Subjects:
Computer simulation
Couplings
Dimerization
Formations
Ligands
Receptors
State vectors
Online Access:Get full text
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Summary:While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via minimal representations of physical observables, effects arising from higher-order oligomer (e.g., trimer and tetramer) formations of unobserved receptors have received less attention. Here, we propose a dimerization model of ligand-induced receptors in multivalent form representing physical observables under basis vectors of various aggregated receptor-states. Our simulations of multivalent models not only reject Wofsy-Goldstein parameter conditions for cooperativity, but show higher-order oligomer formations can shift cooperativity from positive to negative.
ISSN:2331-8422
DOI:10.48550/arxiv.1905.11036