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Chronic effects of fumonisin B₁ on ducks

Partially purified fumonisin B1 (FB1) was orally administrated for 77 d to 5 groups of 8 mule ducks starting at 7 d of age; the concentrations corresponded to 5 diets containing 0, 2, 8, 32, and 128 mg of FB1/kg of feed. No mortality was observed, and no effects on feed consumption and body weight g...

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Published in:Poultry science 2005, Vol.84 (1), p.22-28
Main Authors: Tran, S.T, Auvergne, A, Benard, G, Bailly, J.D, Tardieu, D, Babile, R, Guerre, P
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cited_by cdi_FETCH-LOGICAL-c2872-4a8690c657601d83f89f7c33570a685236b928023871879a185b3b6f288ee73c3
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description Partially purified fumonisin B1 (FB1) was orally administrated for 77 d to 5 groups of 8 mule ducks starting at 7 d of age; the concentrations corresponded to 5 diets containing 0, 2, 8, 32, and 128 mg of FB1/kg of feed. No mortality was observed, and no effects on feed consumption and body weight gain were observed at the end of the treatment period. But, surprisingly, FB1 ingested at 32 and 128 mg/kg led to decreased body weight from d 28 to 63 and from d 7 to 63, respectively. FB1 had no effect on the relative weight of heart and breast muscle, whereas a significant increases in the relative weights of gizzard, spleen, and liver were measured in ducks receiving 32 and 128 mg of FB1/kg of feed without evidence of detectable microscopic modification of these organs. FB1 had no significant effect of the serum aspartate aminotransferase and gamma-glutamyltransferase levels but increased serum total protein, cholesterol, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase levels when 128 mg of FB1/kg of feed was given. Serum, liver, and kidney sphinganine to sphingosine ratio was significantly increased in ducks fed 8 to 128 mg of FB1/kg of feed. The biggest increase was observed in kidneys, suggesting that this organ is the most sensitive to detect FB1-induced disruption of sphingolipid metabolism.
doi_str_mv 10.1093/ps/84.1.22
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identifier ISSN: 0032-5791
ispartof Poultry science, 2005, Vol.84 (1), p.22-28
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1525-3171
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recordid cdi_proquest_journals_223152642
source ScienceDirect
subjects Alanine Transaminase - blood
Alkaline Phosphatase - blood
animal organs
Animals
blood chemistry
Blood Proteins - analysis
Body Weight - drug effects
Cholesterol - blood
chronic toxicity
Diet
dose response
Ducks - metabolism
Fumonisins - administration & dosage
Fumonisins - toxicity
hepatotoxicity
Kidney - chemistry
Kidney - drug effects
kidneys
L-Lactate Dehydrogenase - blood
long term effects
Organ Size - drug effects
Sphingosine - analogs & derivatives
Sphingosine - analysis
Sphingosine - blood
weight
title Chronic effects of fumonisin B₁ on ducks
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