Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum

Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation....

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2019-05, Vol.33 (10), p.1399-1405
Main Authors: Pu, Zhong-Hui, Liu, Juan, Peng, Cheng, Luo, Min, Zhou, Qin-Mei, Xie, Xiao-Fang, Chen, Ming-Hua, Xiong, Liang
Format: Article
Language:English
Subjects:
Adenosine
adenosine derivatives
Adenosine diphosphate
Agglomeration
Alkaloids
Alkaloids - isolation & purification
Alkaloids - pharmacology
anti-platelet aggregation activity
Aquatic plants
Aspirin
Aspirin - pharmacology
Humans
Ligusticum
Ligusticum - chemistry
Ligusticum striatum
Molecular Structure
Neostriatum
nucleoside
Nucleosides
Nucleosides - pharmacology
Platelet Activating Factor
Platelet aggregation
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - chemistry
Platelet Aggregation Inhibitors - isolation & purification
Platelet Aggregation Inhibitors - pharmacology
Rhizome - chemistry
Rhizomes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of 3 was equivalent to aspirin.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1416382