Cellular Compatibility Analysis of nHAp/PPC Membrane

Objective: This study aims to analyse the cellular compatibility of the membrane made of poly (propylene carbonate) (PPC) and nanohydroxyapatite (nHAp) by solvent casting/particulate leaching. Experimental Methods: Observating the surface characters of different compositions nHAp/PPC membrane (0 wt%...

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Bibliographic Details
Published in:Journal of Hard Tissue Biology 2019, Vol.28(1), pp.31-36
Main Authors: Lan, Chuanjian, Xiang, Xingchen, Gao, Xing, Sun, Duo, Pan, Yongsheng, Li, Jiang
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Cell proliferation
Compatibility
Cytotoxicity
Experimental methods
Guided bone regeneration technique
Leaching
Nanohydroxyapatite
Poly (propylene carbonate)
Propylene
Scanning electron microscopy
Solvent casting/particulate leaching
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Summary:Objective: This study aims to analyse the cellular compatibility of the membrane made of poly (propylene carbonate) (PPC) and nanohydroxyapatite (nHAp) by solvent casting/particulate leaching. Experimental Methods: Observating the surface characters of different compositions nHAp/PPC membrane (0 wt%, 10 wt%, 20 wt%, 30 wt%, and 40 wt% nHAp), and evaluating its compatibility with MG63 cells. Results: Scanning electron microscopy showed that with the increased nHAp content, the roughness of the membrane surface increased. The results from our in vitro studies indicated that the MG63 cells cultured with nHAp/PPC membrane did not appear to have cytotoxic responses, and the nHAp/PPC membrane could improve the proliferation of MG63 cells when compared to controls (p < 0.05). Additionally, the cell activity, total protein, and alkaline phosphatase increased with the increased nHAp content.
ISSN:1341-7649
1880-828X
DOI:10.2485/jhtb.28.31