Preparation and Characteristics of a Novel Sustained and Controlled Release Drug Delivery Device by Plasma Technique

We have developed a sustained release drug delivery system by formation of a number of fine-micropores with pore sizes mostly ranging from 2 to 10 µm on the outer layer of two-layer tablet with plasma technique. The drug release profile from this system was confirmed in in vitro dissolution experime...

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Bibliographic Details
Published in:Journal of Photopolymer Science and Technology 2016/06/21, Vol.29(3), pp.447-450
Main Authors: Yamauchi, Yukinori, Kuzuya, Masayuki, Sasai, Yasushi, Doi, Naoki, Kondo, Shin-ichi
Format: Article
Language:English
Subjects:
cellulose derivatives
Controlled release
Disintegration
Dissolution
drug delivery system
Drug delivery systems
oxygen plasma irradiation
Pharmacology
Sustained release
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Summary:We have developed a sustained release drug delivery system by formation of a number of fine-micropores with pore sizes mostly ranging from 2 to 10 µm on the outer layer of two-layer tablet with plasma technique. The drug release profile from this system was confirmed in in vitro dissolution experiments. From the beginning of the dissolution test, a uniform release of drug was shown for more than 8 hours without spontaneous disintegration, and sustained release followed during 24-hours period. The results suggest that this system with plasma technique could be useful tool for the formulation strategy to obtain the desirable modulation of accurate drug release kinetics profile, according to its pharmaco- kinetics and therapeutic needs.
ISSN:0914-9244
1349-6336
DOI:10.2494/photopolymer.29.447