Surface modification of zirconia substrate by silicon-substituted hydroxyapatite coating for enhanced bioactivity

In this study, the surface of zirconia (ZrO2) substrates was modified by the combination of plasma treatment and coating with silicon-substituted hydroxyapatite (Si-HA) sols, comprising an expected theoretical Si content of 0 (Si-HA0), 1.70 (Si-HA1), 3.44 (Si-HA2), and 7.01 wt % (Si-HA4) for improvi...

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Bibliographic Details
Published in:Journal of the Ceramic Society of Japan 2018/11/01, Vol.126(11), pp.940-947
Main Authors: CHA, Ju-Young, KIM, Chun-Ho, KIM, Young-Jin
Format: Article
Language:English
Subjects:
Bioactivity
Biocompatibility
Biomedical materials
Coating
Crystal structure
Deionization
Hydroxyapatite
Osteoblasts
Phase composition
Silicon substrates
Silicon-substituted hydroxyapatite
Substitutes
Surface modification
Surgical implants
Tissue engineering
Zirconia
Zirconium dioxide
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Summary:In this study, the surface of zirconia (ZrO2) substrates was modified by the combination of plasma treatment and coating with silicon-substituted hydroxyapatite (Si-HA) sols, comprising an expected theoretical Si content of 0 (Si-HA0), 1.70 (Si-HA1), 3.44 (Si-HA2), and 7.01 wt % (Si-HA4) for improving the biological performance of substrate. The Si-HA-coating layers were successfully deposited on the ZrO2 substrate surface. These coating layers exhibited a three-dimensional interconnected microporous structure and a single-phase crystal owing to HA, implying that the Si content hardly affects the phase composition and microstructure of the coating layers. The dissolution rate of the Si-HA coating layers in deionized water increased with the Si content, which affected the proliferation of mouse calvaria pre-osteoblasts (MC3T3-E1). Cytocompatibility test results revealed that Zr-Si-HA2 substrate, which was coated with Si-HA2, promoted the proliferation and differentiation of MC3T3-E1 more rapidly than the other substrates. These results revealed that Zr-Si-HA substrates are ideal biomaterials for bone tissue engineering.
ISSN:1882-0743
1348-6535
DOI:10.2109/jcersj2.18108