Lipase‐Powered Mesoporous Silica Nanomotors for Triglyceride Degradation

We report lipase‐based nanomotors that are capable of enhanced Brownian motion over long periods of time in triglyceride solution and of degrading triglyceride droplets that mimic “blood lipids”. We achieved about 40 min of enhanced diffusion of lipase‐modified mesoporous silica nanoparticles (MSNPs...

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Bibliographic Details
Published in:Angewandte Chemie 2019-06, Vol.131 (24), p.8076-8080
Main Authors: Wang, Lei, Hortelão, Ana C., Huang, Xin, Sánchez, Samuel
Format: Article
Language:English
Subjects:
Biodegradation
Biomedical materials
Brownian motion
Chemistry
Diffusion coefficient
Droplets
Eigenantrieb
Enhanced diffusion
Environmental degradation
Enzym-Nanomotoren
Lipase
Lipasen
Lipids
Mikromotoren
Nanoparticles
Oil spills
Silica
Silicon dioxide
Substrates
Triacetin
Triglycerides
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Summary:We report lipase‐based nanomotors that are capable of enhanced Brownian motion over long periods of time in triglyceride solution and of degrading triglyceride droplets that mimic “blood lipids”. We achieved about 40 min of enhanced diffusion of lipase‐modified mesoporous silica nanoparticles (MSNPs) through a biocatalytic reaction between lipase and its corresponding water‐soluble oil substrate (triacetin) as fuel, which resulted in an enhanced diffusion coefficient (ca. 50 % increase) at low triacetin concentration (
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201900697