Effect of side chain variation on surface and biological properties of poly(2-alkyl-2-oxazoline) multilayers

[Display omitted] •Multilayers of poly(2-alkyl-2-oxazoline)s with varying side chains were constructed.•Surface properties of films were affected by the chemical nature of PAOX side chain.•Multilayers released different amount of Ciprofloxacin at acidic pH and 37 °C.•Surface properties were correlat...

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Bibliographic Details
Published in:European polymer journal 2019-05, Vol.114, p.452-463
Main Authors: Cagli, Eda, Ugur, Esma, Ulusan, Sinem, Banerjee, Sreeparna, Erel-Goktepe, Irem
Format: Article
Language:English
Subjects:
Acids
Adhesives
Antiadhesive
Antibacterial
Antimicrobial agents
Biological properties
Chains
Drug delivery systems
E coli
Layer-by-layer
Morphology
Multilayers
Organic chemistry
Poly(2-alkyl-2-oxazoline)s
Self-assembly
Serum albumin
Stimuli-responsive drug release
Surface roughness
Surface stability
Tannic acid
Wettability
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Summary:[Display omitted] •Multilayers of poly(2-alkyl-2-oxazoline)s with varying side chains were constructed.•Surface properties of films were affected by the chemical nature of PAOX side chain.•Multilayers released different amount of Ciprofloxacin at acidic pH and 37 °C.•Surface properties were correlated with biological properties of the films. Multilayers of poly(2-alkyl-2-oxazoline)s (PAOX) with varying side chains were constructed through layer-by-layer (LbL) self-assembly using Tannic Acid (TA). Surface morphology, stability, wettability and stimuli-responsive drug release properties of the films were correlated with antiadhesive and antibacterial properties of the multilayers. Thickness, roughness, wettability and stability of multilayers were affected by the chemical nature of PAOX side chain, phase behaviour of PAOX and the binding strength between the layers. PAOX-multilayers released remarkably different amounts of Ciprofloxacin (CIP) especially at acidic pH and 37 °C. Antibacterial activity of the films against S. aureus was in good agreement with the amounts of CIP released from multilayers. Despite the differences in the released CIP amount, PAOX-multilayers showed similar antibacterial activity against E. coli under all conditions. Multilayers with greater wettability exhibited greater resistance against Bovine Serum Albumin (BSA) adsorption and were more effective to reduce adherence of E. coli. None of the PAOX-films exhibited antiadhesiveness against S. aureus.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2019.02.031