Treatment of Post Transfusion Graft‐Versus‐Host Disease

Background and Objectives: In Japan, so many cases of post‐transfusion graft‐versus‐host disease (PT‐GVHD) have been reported, and no effective treatment has been reported. Materials and Methods: Results: Totally 61 cases of PT‐GVHD have been collected, and their background were analyzed. A serine p...

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Bibliographic Details
Published in:Vox sanguinis 2000-01, Vol.78 (S2), p.277-279
Main Authors: Juji, Takeo, Nishimura, Motoko, Tadokoro, Kenji
Format: Article
Language:English
Subjects:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - standards
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Drug Evaluation
Female
Graft vs Host Disease - drug therapy
Graft vs Host Disease - epidemiology
Graft vs Host Disease - etiology
Guanidines - administration & dosage
Guanidines - adverse effects
Guanidines - standards
Humans
Male
Medical sciences
Middle Aged
Serine Proteinase Inhibitors - adverse effects
Serine Proteinase Inhibitors - standards
Serine Proteinase Inhibitors - therapeutic use
Transfusion Reaction
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Treatment Outcome
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Summary:Background and Objectives: In Japan, so many cases of post‐transfusion graft‐versus‐host disease (PT‐GVHD) have been reported, and no effective treatment has been reported. Materials and Methods: Results: Totally 61 cases of PT‐GVHD have been collected, and their background were analyzed. A serine protease inhibitor, nafamostat mesilate(N.M.) was examined as a drug for treatment of PT‐GVHD using 4 patients. Results: N.M. was confirmed to inhibit cytotoxic activities of established cytotoxic T cell (CTL) clones in vitro. Simultaneously it was confirmed that fever and skin rash disappeared and liver function tests were normalized soon after the administration of N.M. in all four cases. Leukopenia and thrombocytopenia simultaneously improved. Conclusion: The effects of N.M. seem to be limited to inhibit cytotoxic activity of CTL. In addition to this drug, how to remove the CTL from the patients will be the essentially important theme for the future.
ISSN:0042-9007
1423-0410
DOI:10.1111/j.1423-0410.2000.tb00079.x