Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study

Background The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. Methods This is a single-arm prospective study according to intervention protoc...

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Published in:Oral and maxillofacial surgery 2019-09, Vol.23 (3), p.297-305
Main Authors: Muraki, Yumi, Akashi, Masaya, Ejima, Yasuo, Hasegawa, Takumi, Miyawaki, Daisuke, Shinomiya, Hirotaka, Nishii, Mika, Otsuki, Naoki, Sasaki, Ryohei, Nibu, Ken-ichi, Komori, Takahide
Format: Article
Language:English
Subjects:
Cancer therapies
Dental care
Dental implants
Drug dosages
Head & neck cancer
Hematology
Intervention
Jaw
Maxillofacial surgery
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Original Article
Radiation therapy
Stem cells
Studies
Systematic review
Transplants & implants
University graduates
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Summary:Background The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. Methods This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. Results Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. Conclusions Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.
ISSN:1865-1550
1865-1569
DOI:10.1007/s10006-019-00783-0