Fabrication of an antibiotic-sensitive 2D-molecularly imprinted photonic crystal

A molecularly imprinted colloidal array (MICA) for the detection of clindamycin hydrochloride (CLI) was prepared by embedding a two-dimensional (2D) polystyrene crystalline colloidal array within a CLI-imprinted hydrogel. The MICA showed a significant response to CLI, in which the particle spacing o...

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Bibliographic Details
Published in:Analytical methods 2019-06, Vol.11 (22), p.2875-2879
Main Authors: Wang, Yi-fei, Fan, Jing, Meng, Zi-hui, Xue, Min, Qiu, Li-li
Format: Article
Language:English
Subjects:
Antibiotics
Clindamycin
Embedding
Fabrication
Hydrogels
Lincomycin
Mica
Molecular imprinting
Photonic crystals
Polystyrene
Polystyrene resins
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Summary:A molecularly imprinted colloidal array (MICA) for the detection of clindamycin hydrochloride (CLI) was prepared by embedding a two-dimensional (2D) polystyrene crystalline colloidal array within a CLI-imprinted hydrogel. The MICA showed a significant response to CLI, in which the particle spacing of the MICA changed 41 nm within 10 min in response to 1 mM CLI, and the structural color of the MICA changed from blue, green, to yellow, and finally, to red. Furthermore, MICA was also used to detect a similar antibiotic, lincomycin, which had only induced a 10 nm change in the spacing. The MICA was reused more than 5 times. This low-cost and naked-eye sensing material provides a label-free way to detect CLI and other antibiotics. A 2D-molecularly imprinted colloidal array was fabricated for the visual detection of clindamycin hydrochloride and the LOD is 0.01 mM.
ISSN:1759-9660
1759-9679
DOI:10.1039/c9ay00674e