Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities

Five new aromatic compounds, designed as lucidumins A-D (1–4) and lucidimine E (9), along with seven known aromatic compounds (5–8, 10–12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed...

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Bibliographic Details
Published in:Fitoterapia 2019-04, Vol.134, p.58-64
Main Authors: Lu, Shuang-Yang, Peng, Xing-Rong, Dong, Jin-Run, Yan, Hui, Kong, Qing-Hua, Shi, Qiang-Qiang, Li, Da-Shan, Zhou, Lin, Li, Zhong-Rong, Qiu, Ming-Hua
Format: Article
Language:English
Subjects:
Anti-inflammatory activity
Aromatic compounds
Aromatic constituents
Cell viability
Corticosterone
Depression
Ganoderma lucidum
Inflammation
Lipopolysaccharides
Macrophages
Mushrooms
Neuroprotection
Neuroprotective activity
Nitric oxide
Pheochromocytoma cells
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Summary:Five new aromatic compounds, designed as lucidumins A-D (1–4) and lucidimine E (9), along with seven known aromatic compounds (5–8, 10–12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1–4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with IC50 values ranging from 4.68 to 15.49 μM. In particular, compound 10 showed remarkable neuroprotection with EC50 value of 2.49 ± 0.12 μM, and potent anti-inflammation with IC50 value of 4.68 ± 0.09 μM. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.01.013