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Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities
Five new aromatic compounds, designed as lucidumins A-D (1–4) and lucidimine E (9), along with seven known aromatic compounds (5–8, 10–12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed...
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| Published in: | Fitoterapia 2019-04, Vol.134, p.58-64 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| container_end_page | 64 |
| container_issue | |
| container_start_page | 58 |
| container_title | Fitoterapia |
| container_volume | 134 |
| creator | Lu, Shuang-Yang Peng, Xing-Rong Dong, Jin-Run Yan, Hui Kong, Qing-Hua Shi, Qiang-Qiang Li, Da-Shan Zhou, Lin Li, Zhong-Rong Qiu, Ming-Hua |
| description | Five new aromatic compounds, designed as lucidumins A-D (1–4) and lucidimine E (9), along with seven known aromatic compounds (5–8, 10–12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1–4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with IC50 values ranging from 4.68 to 15.49 μM. In particular, compound 10 showed remarkable neuroprotection with EC50 value of 2.49 ± 0.12 μM, and potent anti-inflammation with IC50 value of 4.68 ± 0.09 μM.
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| doi_str_mv | 10.1016/j.fitote.2019.01.013 |
| format | article |
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[Display omitted]</description><subject>Anti-inflammatory activity</subject><subject>Aromatic compounds</subject><subject>Aromatic constituents</subject><subject>Cell viability</subject><subject>Corticosterone</subject><subject>Depression</subject><subject>Ganoderma lucidum</subject><subject>Inflammation</subject><subject>Lipopolysaccharides</subject><subject>Macrophages</subject><subject>Mushrooms</subject><subject>Neuroprotection</subject><subject>Neuroprotective activity</subject><subject>Nitric oxide</subject><subject>Pheochromocytoma cells</subject><issn>0367-326X</issn><issn>1873-6971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9UMFKAzEQDaJgrf6BhwXPuyab3bS5CKVoFQpeFLyFbDLRLN2kJtlC_97U9Sw8GJiZ997MQ-iW4Ipgwu77ytjkE1Q1JrzCJIOeoRlZLmjJ-IKcoxmmbFHSmn1coqsYe4xJSxsyQ5-r4AeZrCqUdzHZNIJLsTC5W2yk8xrCIIvdqKweh0I6XaQvsKFwMAa_D9lUJXuA34l0yZbWmZ0csqQPx0KehjZZiNfowshdhJu_OkfvT49v6-dy-7p5Wa-2paIcpxIkEK4MNAyrRuGlxGA6oLhl0Ml22cqGUs2AKa7rjreaU-g4a1sjGekY03SO7ibdfNv3CDGJ3o_BZUtR15QR1ta0yVvNtKWCjzGAEftgBxmOgmBxilT0YopUnCIVmGTQTHuYaJA_OFgIIioLToG2IecgtLf_C_wAAzqE3Q</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Lu, Shuang-Yang</creator><creator>Peng, Xing-Rong</creator><creator>Dong, Jin-Run</creator><creator>Yan, Hui</creator><creator>Kong, Qing-Hua</creator><creator>Shi, Qiang-Qiang</creator><creator>Li, Da-Shan</creator><creator>Zhou, Lin</creator><creator>Li, Zhong-Rong</creator><creator>Qiu, Ming-Hua</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20190401</creationdate><title>Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities</title><author>Lu, Shuang-Yang ; 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Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1–4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with IC50 values ranging from 4.68 to 15.49 μM. In particular, compound 10 showed remarkable neuroprotection with EC50 value of 2.49 ± 0.12 μM, and potent anti-inflammation with IC50 value of 4.68 ± 0.09 μM.
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| ispartof | Fitoterapia, 2019-04, Vol.134, p.58-64 |
| issn | 0367-326X 1873-6971 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Anti-inflammatory activity Aromatic compounds Aromatic constituents Cell viability Corticosterone Depression Ganoderma lucidum Inflammation Lipopolysaccharides Macrophages Mushrooms Neuroprotection Neuroprotective activity Nitric oxide Pheochromocytoma cells |
| title | Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities |
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