Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar

Four new bis-iridoid glycosides, saungmaygaosides A-D (1–4), and six known iridoid glycosides (5–10) were isolated from the n-butanol extract of the stems of Picrorhiza kurroa collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were assay...

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Bibliographic Details
Published in:Fitoterapia 2019-04, Vol.134, p.101-107
Main Authors: Win, Nwet Nwet, Kodama, Takeshi, Lae, Khine Zar Wynn, Win, Yi Yi, Ngwe, Hla, Abe, Ikuro, Morita, Hiroyuki
Format: Article
Language:English
Subjects:
Anti-Vpr activity
Bis-iridoid glycosides
Butanol
Dimethyl acetals
Glycosides
Inhibitors
Iridoid glycosides
Picrorhiza kurroa
Saungmaygaosides
TREx-HeLa-Vpr cells
Vpr protein
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Summary:Four new bis-iridoid glycosides, saungmaygaosides A-D (1–4), and six known iridoid glycosides (5–10) were isolated from the n-butanol extract of the stems of Picrorhiza kurroa collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were assayed for anti-Vpr activity, using TREx-HeLa-Vpr cells. Among the isolates, saungmaygaoside D (4), sylvestroside IV dimethyl acetal (7), and sweroside (8) were the most potent inhibitors with effective doses of 5 and 10 μM, respectively, without showing any notable cytotoxicities. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.02.016