Loading…
Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease
The frequency of genotypic variants for the rs2010963 polymorphism in the gene for vascular endothelial growth factor (VEGF) was analyzed in 140 patients with rosacea in 145 almost healthy persons of Uzbek nationality. It was shown that the distribution of genotypes in the studied groups corresponde...
Saved in:
| Published in: | Cytology and genetics 2019-05, Vol.53 (3), p.233-238 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73 |
| container_end_page | 238 |
| container_issue | 3 |
| container_start_page | 233 |
| container_title | Cytology and genetics |
| container_volume | 53 |
| creator | Babadjanov, O. A. Karimov, H. Ya Arifov, S. S. Boboev, K. T. |
| description | The frequency of genotypic variants for the rs2010963 polymorphism in the gene for vascular endothelial growth factor (VEGF) was analyzed in 140 patients with rosacea in 145 almost healthy persons of Uzbek nationality. It was shown that the distribution of genotypes in the studied groups corresponded to the Hardy–Weinberg equilibrium (
p
> 0.05). Significant differences in the frequency of occurrence for rs2010963 alleles of the
VEGF
gene were found between groups of patients with rosacea with different clinical subtypes of the disease and a group of almost healthy individuals (
p
< 0.05). Carrying a functionally unfavorable allele
VEGF
634C in the hetero- or homozygous variant significantly increases the risk of developing rosacea. The data indicate the association of this DNA locus with the formation of rosacea in the Uzbek population. |
| doi_str_mv | 10.3103/S0095452719030083 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2236745116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2236745116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73</originalsourceid><addsrcrecordid>eNp1kc1OwzAQhC0EEuXnAbhZ4hzYtROnOaJSChISqPxcI9fZUKM0DrYL6qPwtqQtiAPitCvNfDOHYewE4UwiyPMHgCJLM5FjARJgKHfYAAuZJkWawi4brOVkre-zgxBeATIlpBywz_G7bpY6Wtdy20bH45z41DXEXb35n8eTKz6hlvi9a1YL57u5DQvugwCEQsme2vgu6Z0a1y2ojWt06oI2pLluK25j4FNqNiVhbjv-YeOcjxrbWqMb_rCcxVVH4afx0gbSgY7YXq2bQMff95A9XY0fR9fJ7d3kZnRxmxiJKibSoDJAhUrlUBOBgHyGqcZMqqpSaARiXWEl6mGaFxkACoMC5UxIo0lQLg_Z6Ta38-5tSSGWr27p276yFEKqPM0QVe_Crct4F4Knuuy8XWi_KhHK9QLlnwV6RmyZ0HvbF_K_yf9DX-JPht8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2236745116</pqid></control><display><type>article</type><title>Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease</title><source>Springer Link</source><creator>Babadjanov, O. A. ; Karimov, H. Ya ; Arifov, S. S. ; Boboev, K. T.</creator><creatorcontrib>Babadjanov, O. A. ; Karimov, H. Ya ; Arifov, S. S. ; Boboev, K. T.</creatorcontrib><description>The frequency of genotypic variants for the rs2010963 polymorphism in the gene for vascular endothelial growth factor (VEGF) was analyzed in 140 patients with rosacea in 145 almost healthy persons of Uzbek nationality. It was shown that the distribution of genotypes in the studied groups corresponded to the Hardy–Weinberg equilibrium (
p
> 0.05). Significant differences in the frequency of occurrence for rs2010963 alleles of the
VEGF
gene were found between groups of patients with rosacea with different clinical subtypes of the disease and a group of almost healthy individuals (
p
< 0.05). Carrying a functionally unfavorable allele
VEGF
634C in the hetero- or homozygous variant significantly increases the risk of developing rosacea. The data indicate the association of this DNA locus with the formation of rosacea in the Uzbek population.</description><identifier>ISSN: 0095-4527</identifier><identifier>EISSN: 1934-9440</identifier><identifier>DOI: 10.3103/S0095452719030083</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Alleles ; Biomedical and Life Sciences ; Biomedicine ; Gene polymorphism ; Human Genetics ; Polymorphism ; Rosacea ; Vascular endothelial growth factor</subject><ispartof>Cytology and genetics, 2019-05, Vol.53 (3), p.233-238</ispartof><rights>Allerton Press, Inc. 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73</citedby><cites>FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Babadjanov, O. A.</creatorcontrib><creatorcontrib>Karimov, H. Ya</creatorcontrib><creatorcontrib>Arifov, S. S.</creatorcontrib><creatorcontrib>Boboev, K. T.</creatorcontrib><title>Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease</title><title>Cytology and genetics</title><addtitle>Cytol. Genet</addtitle><description>The frequency of genotypic variants for the rs2010963 polymorphism in the gene for vascular endothelial growth factor (VEGF) was analyzed in 140 patients with rosacea in 145 almost healthy persons of Uzbek nationality. It was shown that the distribution of genotypes in the studied groups corresponded to the Hardy–Weinberg equilibrium (
p
> 0.05). Significant differences in the frequency of occurrence for rs2010963 alleles of the
VEGF
gene were found between groups of patients with rosacea with different clinical subtypes of the disease and a group of almost healthy individuals (
p
< 0.05). Carrying a functionally unfavorable allele
VEGF
634C in the hetero- or homozygous variant significantly increases the risk of developing rosacea. The data indicate the association of this DNA locus with the formation of rosacea in the Uzbek population.</description><subject>Alleles</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Gene polymorphism</subject><subject>Human Genetics</subject><subject>Polymorphism</subject><subject>Rosacea</subject><subject>Vascular endothelial growth factor</subject><issn>0095-4527</issn><issn>1934-9440</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kc1OwzAQhC0EEuXnAbhZ4hzYtROnOaJSChISqPxcI9fZUKM0DrYL6qPwtqQtiAPitCvNfDOHYewE4UwiyPMHgCJLM5FjARJgKHfYAAuZJkWawi4brOVkre-zgxBeATIlpBywz_G7bpY6Wtdy20bH45z41DXEXb35n8eTKz6hlvi9a1YL57u5DQvugwCEQsme2vgu6Z0a1y2ojWt06oI2pLluK25j4FNqNiVhbjv-YeOcjxrbWqMb_rCcxVVH4afx0gbSgY7YXq2bQMff95A9XY0fR9fJ7d3kZnRxmxiJKibSoDJAhUrlUBOBgHyGqcZMqqpSaARiXWEl6mGaFxkACoMC5UxIo0lQLg_Z6Ta38-5tSSGWr27p276yFEKqPM0QVe_Crct4F4Knuuy8XWi_KhHK9QLlnwV6RmyZ0HvbF_K_yf9DX-JPht8</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Babadjanov, O. A.</creator><creator>Karimov, H. Ya</creator><creator>Arifov, S. S.</creator><creator>Boboev, K. T.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190501</creationdate><title>Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease</title><author>Babadjanov, O. A. ; Karimov, H. Ya ; Arifov, S. S. ; Boboev, K. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alleles</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Gene polymorphism</topic><topic>Human Genetics</topic><topic>Polymorphism</topic><topic>Rosacea</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babadjanov, O. A.</creatorcontrib><creatorcontrib>Karimov, H. Ya</creatorcontrib><creatorcontrib>Arifov, S. S.</creatorcontrib><creatorcontrib>Boboev, K. T.</creatorcontrib><collection>CrossRef</collection><jtitle>Cytology and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babadjanov, O. A.</au><au>Karimov, H. Ya</au><au>Arifov, S. S.</au><au>Boboev, K. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease</atitle><jtitle>Cytology and genetics</jtitle><stitle>Cytol. Genet</stitle><date>2019-05-01</date><risdate>2019</risdate><volume>53</volume><issue>3</issue><spage>233</spage><epage>238</epage><pages>233-238</pages><issn>0095-4527</issn><eissn>1934-9440</eissn><abstract>The frequency of genotypic variants for the rs2010963 polymorphism in the gene for vascular endothelial growth factor (VEGF) was analyzed in 140 patients with rosacea in 145 almost healthy persons of Uzbek nationality. It was shown that the distribution of genotypes in the studied groups corresponded to the Hardy–Weinberg equilibrium (
p
> 0.05). Significant differences in the frequency of occurrence for rs2010963 alleles of the
VEGF
gene were found between groups of patients with rosacea with different clinical subtypes of the disease and a group of almost healthy individuals (
p
< 0.05). Carrying a functionally unfavorable allele
VEGF
634C in the hetero- or homozygous variant significantly increases the risk of developing rosacea. The data indicate the association of this DNA locus with the formation of rosacea in the Uzbek population.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.3103/S0095452719030083</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0095-4527 |
| ispartof | Cytology and genetics, 2019-05, Vol.53 (3), p.233-238 |
| issn | 0095-4527 1934-9440 |
| language | eng |
| recordid | cdi_proquest_journals_2236745116 |
| source | Springer Link |
| subjects | Alleles Biomedical and Life Sciences Biomedicine Gene polymorphism Human Genetics Polymorphism Rosacea Vascular endothelial growth factor |
| title | Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T17%3A09%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20into%20the%20Role%20of%20the%20VEGF%20Gene%20Polymorphism%20rs2010963%20in%20the%20Development%20of%20Rosacea%20and%20its%20Relationship%20with%20Clinical%20Subtypes%20of%20the%20Disease&rft.jtitle=Cytology%20and%20genetics&rft.au=Babadjanov,%20O.%20A.&rft.date=2019-05-01&rft.volume=53&rft.issue=3&rft.spage=233&rft.epage=238&rft.pages=233-238&rft.issn=0095-4527&rft.eissn=1934-9440&rft_id=info:doi/10.3103/S0095452719030083&rft_dat=%3Cproquest_cross%3E2236745116%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c316t-3c16c0e96438aee0207b14a1536dd61c211fd1d2f847950012c1213b23cae2e73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2236745116&rft_id=info:pmid/&rfr_iscdi=true |