AMINOACYL-tRNA SYNTHESIS

Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is to precisely match amino acids with tRNAs containing the corresponding anticodon. This is primarily achieved by the direct att...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of biochemistry 2000-01, Vol.69 (1), p.617-650
Main Authors: Ibba, Michael, Söll, Dieter
Format: Article
Language:English
Subjects:
Amino acids
aminoacyl-tRNA ligase
aminoacyl-tRNA synthetase
Animals
Bacteria - metabolism
Bacteria - pathogenicity
Bacterial Infections - diagnosis
Bacterial Infections - drug therapy
Biological Evolution
Enzyme Inhibitors - therapeutic use
evolution
Humans
Models, Molecular
RNA, Transfer, Amino Acyl - biosynthesis
RNA, Transfer, Amino Acyl - chemistry
RNA, Transfer, Amino Acyl - genetics
transamidation
transfer RNA
translation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is to precisely match amino acids with tRNAs containing the corresponding anticodon. This is primarily achieved by the direct attachment of an amino acid to the corresponding tRNA by an aminoacyl-tRNA synthetase, although intrinsic proofreading and extrinsic editing are also essential in several cases. Recent studies of aminoacyl-tRNA synthesis, mainly prompted by the advent of whole genome sequencing and the availability of a vast body of structural data, have led to an expanded and more detailed picture of how aminoacyl-tRNAs are synthesized. This article reviews current knowledge of the biochemical, structural, and evolutionary facets of aminoacyl-tRNA synthesis.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.biochem.69.1.617