Evaluation of behavioural and cognitive effects against diabetic model in young and adult rats

INTRODUCTION Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action or both .Type 1 diabetes (idiopathic or immune mediated) or Type 2 diabetes (combination of progressive insulin resistance and ß-cell failure)....

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2019-05, Vol.11 (5), p.1803-1807
Main Authors: Ratna, B, John, Johnson C
Format: Article
Language:English
Subjects:
Alcohol
Animal cognition
Behavior
Biochemistry
Defects
Deoxyribonucleic acid
Diabetes
DNA
Glucose
Hyperglycemia
Information processing
Insulin resistance
Memory
Metabolism
Nervous system
Neurosciences
PCB
Pharmacology
Polychlorinated biphenyls
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:INTRODUCTION Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action or both .Type 1 diabetes (idiopathic or immune mediated) or Type 2 diabetes (combination of progressive insulin resistance and ß-cell failure). Complications of diabetes includes cardiovascular disease ,nerve Damage (neuropathy) kidney damage (nephropathy),eye disease (retinopathy), oral Health, osteoporosis ,diabetic Foot cognitive and memory defects etc. slowing of information processing ,psychomotor efficiency. Discussion Diabetes mellitus is one of the major metabolic disorders characterized by hyperglycaemia resulting from defects in secretion of insulin, insulin action or life threatening complications that mainly affects the heart, blood vessels, renal system, eye, nerves etc. The results from behavioural study indicated the altered behavioural patterns of the animals.There was an abundant increase in anxiety were observed in all the models against STZ, there was no significant changes in the transfer latency between young and adult diabetic rats.The results from behavioural studies like hole board test, forced swim test locomotions, head dipping /anxiety, immobility/depressive behaviour respectively in the adult rats but there was no significant altered behavioural changes were observed in young diabetic rats which indirectly reveals that younger animals (45 days of age) are suitable for behavioural performance/alteration based studies in relation with diabetes References 1. merican Diabetes Association: diagnosis and classification of diabetes mellitus.
ISSN:0975-1459