Synthesis, Structure and In Vitro Anti-gastric Cancer Activity of Two New Mixed-Ligand Cu(II) and Cd(II)-Coordination Polymers

• Published in: Journal of inorganic and organometallic polymers and materials 2019-07, Vol.29 (4), p.1184-1191
• Main Authors: Wan, Xiao-Long, Dong, Lei, Wang, Jia-Zhong, Shi, Hai-Tao, Yang, Long-Bao
• Format: Article
• Language: English
• Subjects: Anticancer properties; Chemical synthesis; Chemistry; Chemistry and Materials Science; Coordination compounds; Coordination polymers; Crystal structure; Gastric cancer; Inorganic Chemistry; Ligands; Naphthalene; Organic Chemistry; Polymer Sciences; Polymers; Single crystals; X-ray diffraction
• ISSN: 1574-1443; 1574-1451
• DOI: 10.1007/s10904-019-01081-8

By using a strategy of introducing two organic ligands with different donor groups, two new Cu(II) and Cd(II) coordination polymers (CPs) [Cu 3 (OH)(pz) 3 (Hpz)(H 2 O)(ipa)](H 2 O) 4 ( 1 , Hpz = pyrazol, H 2 ipa = isophthalic acid) and [Cd(phen)(ndc)](H 2 O) ( 2 , phen = 1,10-phenanthroline, H 2 ndc = 1,2-naphthalene dicarboxylic acid) are synthesized and characterized. The molecular structures of the as-prepared CPs were determined by the single crystal X-ray diffraction (SCXRD) studies and their phase purities have been confirmed via the power X-day diffraction analysis (PXRD). The Cu(II)-based complex 1 is composed of trinuclear Cu 3 (µ 3 -OH)(pz) 3 clusters that extended by the ipa 2− ligands into a 1D left-handed helical chain along the c axis. In complex 2 , the ndc 2− ligands connect with the binuclear Cd2 unit along the c axis to shape a 1D chain-like structure, which is further stacked into a 2D layered network via π–π stacking. The as-prepared two CPs transformed to the nanoscale regime by mechanical grinding to yield nano 1 and nano 2 with excellent water dispersibility, maintaining its crystallinity. In addition, the in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were conducted on the gastric cancer cell line AGS with increasing concentrations of the two nanosized CPs, which reveal their promising anticancer activity.