Longitudinal and Cross-Sectional Analysis of Cytotoxic T Lymphocyte Responses and Their Relationship to Vertical Human Immunodeficiency Virus Transmission

The ARIEL Project for the Prevention of HIV Transmission from Mother to Infant was established to evaluate virologic and immunologic parameters during vertical transmission. To determine the strength and breadth of the cytotoxic T lymphocyte (CTL) response and its correlation with human immunodefici...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-11, Vol.178 (5), p.1317-1326
Main Authors: Jin, Xia, Roberts, Caroline G. P., Nixon, Douglas F., Cao, Yunzhen, Ho, David D., Walker, Bruce D., Muldoon, Mark, Korber, Bette T. M., Koup, Richard A.
Format: Article
Language:English
Subjects:
AIDS
Antigens
Biological and medical sciences
HIV
HIV 1
Human viral diseases
Infectious diseases
Medical sciences
Pregnancy
Radio transmitters
T lymphocytes
Vertical disease transmission
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
Women
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Summary:The ARIEL Project for the Prevention of HIV Transmission from Mother to Infant was established to evaluate virologic and immunologic parameters during vertical transmission. To determine the strength and breadth of the cytotoxic T lymphocyte (CTL) response and its correlation with human immunodeficiency virus (HIV) transmission, a cross-sectional study was done of 31 HIV-infected pregnant women, of whom 15 transmitted and 16 did not transmit HIV to their infants. The precursor frequencies of CTL specific for HIV-1 gag, pol, nef, and env from 5 different isolates of the clade B of HIV-1 were determined by limiting dilution analysis. Results showed that variable levels of HIV-specific CTL response were present in HIV-infected pregnant women during and after pregnancy. In addition, CTL precursor frequencies specific for pol and nef were higher during pregnancy in nontransmitters than in transmitters. Thus, CTL responding to different HIV antigens may not be contributing equally to the prevention of vertical transmission.
ISSN:0022-1899
1537-6613
DOI:10.1086/314455