Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus—Associated Dementia

A human immunodeficiency virus type 1 (HIV)—seropositive, antiretroviral-naive patient presented with significant cognitive dysfunction. Neuropsychologic, neuroradiologic, immunologic, and virologic studies confirmed HIV-associated dementia (HAD). After 12 weeks of highly active antiretroviral thera...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-10, Vol.178 (4), p.1000-1007
Main Authors: Gendelman, Howard E., Zheng, Jialin, Coulter, Cynthia L., Ghorpade, Anuja, Che, Myhanh, Thylin, Michael, Rubocki, Ronald, Persidsky, Yuri, Hahn, Francis, Reinhard, John, Swindells, Susan
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS Dementia Complex - diagnosis
AIDS Dementia Complex - drug therapy
Anti-HIV Agents - therapeutic use
Atrophy
Biological and medical sciences
Brain
Brain - pathology
Cerebrospinal fluid
Dementia
Female
Highly active antiretroviral therapy
HIV
Human viral diseases
Humans
Ibuprofen - therapeutic use
Indinavir - therapeutic use
Infectious diseases
Lamivudine - therapeutic use
Magnetic Resonance Imaging
Major Articles
Medical sciences
Neurons
Neurons - drug effects
Neurotoxins
Neurotoxins - analysis
Neurotoxins - blood
Neurotoxins - cerebrospinal fluid
Nitric Oxide - blood
Nitric Oxide - cerebrospinal fluid
Quinolinic Acid - blood
Quinolinic Acid - cerebrospinal fluid
RNA
Toxicity Tests
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - cerebrospinal fluid
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
Zidovudine - therapeutic use
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Description
Summary:A human immunodeficiency virus type 1 (HIV)—seropositive, antiretroviral-naive patient presented with significant cognitive dysfunction. Neuropsychologic, neuroradiologic, immunologic, and virologic studies confirmed HIV-associated dementia (HAD). After 12 weeks of highly active antiretroviral therapy (HAART) with ibuprofen, dramatic improvements were demonstrated in neurologic function and were sustained for >1 year. HIV-1 RNA in cerebrospinal fluid (CSF) decreased from 105 to 104 copies/mL after 4 weeks. After 20 weeks of therapy, plasma viremia decreased from 106 copies/mL to undetectable (
ISSN:0022-1899
1537-6613
DOI:10.1086/515693