GP270 Health problems in neonates with perinatal HIV exposure

IntroductionAntenatal and perinatal periods determine the potential of a child’s health for near and distant future. Considering the increasing number of HIV-exposed uninfected newborns (especially in areas of high risk of HIV infection), the aim of our study was to determine the prevalence of healt...

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Bibliographic Details
Published in:Archives of disease in childhood 2019-06, Vol.104 (Suppl 3), p.A143
Main Authors: Shugaeva, Svetlana, Petrova, Alla, Vanyarkina, Anastasiya, Rychkova, Lyubov
Format: Article
Language:English
Subjects:
Children
Childrens health
Comparative Analysis
Congenital defects
Disease transmission
Drug dependence
Families & family life
Family (Sociological Unit)
Growth rate
Health problems
Health risk assessment
HIV
Human immunodeficiency virus
Intellectual Disability
Low Income Groups
Neonatal abstinence syndrome
Neonates
Newborn babies
Pediatrics
Perinatal exposure
Sexual behavior
Sexually transmitted diseases
Statistical analysis
STD
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Summary:IntroductionAntenatal and perinatal periods determine the potential of a child’s health for near and distant future. Considering the increasing number of HIV-exposed uninfected newborns (especially in areas of high risk of HIV infection), the aim of our study was to determine the prevalence of health problems of newborns who avoided perinatal HIV transmission.MethodsWe conducted a cohort randomized study that included 177 children from birth to 18 months of life. The sample was divided in two groups, equivalent in sex: the main group (n = 87, random sample) comprised neonates with perinatal HIV exposure, the comparison group included children with no HIV exposure (matched sample). Exclusion criteria were confirmed HIV infection (n = 3), and parents’ refusal to participate (n = 0). We evaluated the frequency (Pabs/P%) of seven signs (prematurity, intrauterine growth retardation, neonatal abstinence syndrome, abnormalities of postnatal adaptation, perinatal damage of CNS, congenital and perinatally-acquired infections, congenital malformations and/or minor developmental abnormality). A comparative analysis was performed using the χ2 criterion and its modifications (Yates corrected Chi-square, two-tailed Fisher exact p), relative risk index was calculated (RR [CI0.95]).ResultsHealth problems in neonates according to the analyzed signs were significantly more frequent in main group (76/87.6%) than in comparison group (28/31.1%) (RR = 2.8 [2.0–3.9]; χ2 = 57.75, p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2019-epa.329