GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases

Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patie...

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Bibliographic Details
Published in:Archives of disease in childhood 2019-06, Vol.104 (Suppl 3), p.A43
Main Authors: Slastnikova, Evgeniia, Sadykova, Dinara, Leontyeva, Irina, Galimova, Liliya
Format: Article
Language:English
Subjects:
Angina
Aorta
Arteriosclerosis
Atherosclerosis
Blood pressure
Cardiovascular diseases
Children
Childrens health
Control Groups
Coronary artery disease
Dyslipidemia
Families & family life
Family (Sociological Unit)
Genetics
Health risk assessment
Heart diseases
Heredity
Ischemia
Pediatrics
Propagation
Rigidity
Statistical analysis
Wave propagation
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Summary:Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patients were selected (men ≤55 years, women ≤ 60 years). Their children, grandchildren (144 people) (Group 1) aged 5–17 years were examined. Control group of conditionally healthy children (112 people) was formed (Group 2), their family history was collected with the aim of excluding heredity burdened by CVD. A biochemical blood test was performed to determine the lipid profile; thus, a group with dyslipidemia (Group 1a) was selected among children with burdened family history, which included 76 people (53%), lipidogram indicators (Group 1b) that were normal (68 people, 47%). Rigidity indices of main vessels were determined: PTT (pulse wave propagation time), PWVao (pulse wave propagation speed in the aorta), AIx (augmentation index), (dP/dt) max (max blood pressure rise rate). An ambulatory daily monitor, BPLab® software using Vasotens® technology was used.ResultsIn general, in Group 1, the rigidity indicators of the vascular wall were similar (average daily PTT 145.3 ± 15.9 ms, PWVao 6.7 ± 0.9 m/s, AIx 4.9 ± 8.1%, (dP/dt) max 667.9 ± 119.8 mm Hg/s) with those of Group 2 (average daily PTT 140.5 ± 15.2 ms, PWVao 6.4 ± 1.1 m/s, AIx 5.1 ± 8.2%, (dP/dt) max 668.1 ± 121.3 mm Hg/s) and were statistically significant (p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2019-epa.101