GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases

Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patie...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 2019-06, Vol.104 (Suppl 3), p.A43
Main Authors: Slastnikova, Evgeniia, Sadykova, Dinara, Leontyeva, Irina, Galimova, Liliya
Format: Article
Language:English
Subjects:
Angina
Aorta
Arteriosclerosis
Atherosclerosis
Blood pressure
Cardiovascular diseases
Children
Childrens health
Control Groups
Coronary artery disease
Dyslipidemia
Families & family life
Family (Sociological Unit)
Genetics
Health risk assessment
Heart diseases
Heredity
Ischemia
Pediatrics
Propagation
Rigidity
Statistical analysis
Wave propagation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue Suppl 3
container_start_page A43
container_title Archives of disease in childhood
container_volume 104
creator Slastnikova, Evgeniia
Sadykova, Dinara
Leontyeva, Irina
Galimova, Liliya
description Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patients were selected (men ≤55 years, women ≤ 60 years). Their children, grandchildren (144 people) (Group 1) aged 5–17 years were examined. Control group of conditionally healthy children (112 people) was formed (Group 2), their family history was collected with the aim of excluding heredity burdened by CVD. A biochemical blood test was performed to determine the lipid profile; thus, a group with dyslipidemia (Group 1a) was selected among children with burdened family history, which included 76 people (53%), lipidogram indicators (Group 1b) that were normal (68 people, 47%). Rigidity indices of main vessels were determined: PTT (pulse wave propagation time), PWVao (pulse wave propagation speed in the aorta), AIx (augmentation index), (dP/dt) max (max blood pressure rise rate). An ambulatory daily monitor, BPLab® software using Vasotens® technology was used.ResultsIn general, in Group 1, the rigidity indicators of the vascular wall were similar (average daily PTT 145.3 ± 15.9 ms, PWVao 6.7 ± 0.9 m/s, AIx 4.9 ± 8.1%, (dP/dt) max 667.9 ± 119.8 mm Hg/s) with those of Group 2 (average daily PTT 140.5 ± 15.2 ms, PWVao 6.4 ± 1.1 m/s, AIx 5.1 ± 8.2%, (dP/dt) max 668.1 ± 121.3 mm Hg/s) and were statistically significant (p
doi_str_mv 10.1136/archdischild-2019-epa.101
format article
fullrecord <record><control><sourceid>proquest_bmj_p</sourceid><recordid>TN_cdi_proquest_journals_2239155445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2239155445</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1241-b4838e5721b43ef646ad7af9b7e3b88fcf8bfd6bef516048cf00627e544490003</originalsourceid><addsrcrecordid>eNpNkM1KAzEUhYMoWKvvEHE9mkwyM5mlFK1CQUFdh2Ryw6TMT01mLF3pxhf1SUxbFVcXzj2cc--H0Dkll5Sy_Er5qjYuVLVrTJISWiawUpeU0AM0oTwXUeP8EE0IISwphRDH6CSEJSE0FYJN0Pv8kWVfH59Pw2g2uLd4qAGHwVnbQQi_wpsK1dgoj9eqabDr8K7PQ4et71tsVesaBwGv3VBjhfXoDXRgcO3C0PtdbqW8cf1fULwZVIBwio6sagKc_cwperm9eZ7dJYuH-f3sepFomnKaaC6YgKxIqeYMbM5zZQplS10A00LYygptTa7BZjQnXFSWkDwtIOOcl9vfp-hin7vy_esIYZDLfvRdrJRpykqaRWcWXXzv0u1Srrxrld9ISuQWtfyPWm5Ry4g6bin7BlqbeTM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2239155445</pqid></control><display><type>article</type><title>GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases</title><source>Social Science Premium Collection</source><source>Education Collection</source><creator>Slastnikova, Evgeniia ; Sadykova, Dinara ; Leontyeva, Irina ; Galimova, Liliya</creator><creatorcontrib>Slastnikova, Evgeniia ; Sadykova, Dinara ; Leontyeva, Irina ; Galimova, Liliya</creatorcontrib><description>Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patients were selected (men ≤55 years, women ≤ 60 years). Their children, grandchildren (144 people) (Group 1) aged 5–17 years were examined. Control group of conditionally healthy children (112 people) was formed (Group 2), their family history was collected with the aim of excluding heredity burdened by CVD. A biochemical blood test was performed to determine the lipid profile; thus, a group with dyslipidemia (Group 1a) was selected among children with burdened family history, which included 76 people (53%), lipidogram indicators (Group 1b) that were normal (68 people, 47%). Rigidity indices of main vessels were determined: PTT (pulse wave propagation time), PWVao (pulse wave propagation speed in the aorta), AIx (augmentation index), (dP/dt) max (max blood pressure rise rate). An ambulatory daily monitor, BPLab® software using Vasotens® technology was used.ResultsIn general, in Group 1, the rigidity indicators of the vascular wall were similar (average daily PTT 145.3 ± 15.9 ms, PWVao 6.7 ± 0.9 m/s, AIx 4.9 ± 8.1%, (dP/dt) max 667.9 ± 119.8 mm Hg/s) with those of Group 2 (average daily PTT 140.5 ± 15.2 ms, PWVao 6.4 ± 1.1 m/s, AIx 5.1 ± 8.2%, (dP/dt) max 668.1 ± 121.3 mm Hg/s) and were statistically significant (p &lt;0.05). However, it was found that if we consider non-maximum daily indicators, then in Group 1 they were significantly higher (p &lt;0.05) (max daily PTT 199.9 ± 10.2 ms, PWVao 16.3 ± 1.4 m/s, AIx 35.3 ± 3.4%, (dP/dt) max 1098.1 ± 120.5 mm Hg/s) than in Group 2 (max daily PTT 181.7 ± 9.6 ms, PWVao 13.1 ± 1.9 m/s, AIx 28.3 ± 1.4%, (dP/dt) max 1005.1 ± 110.3 mm Hg/s). Comparing the parameters between Group 1a and 1b, no statistically significant difference was found between the mean values, but statistically significant difference was found between the maximum values.ConclusionsDirect relationship has been revealed between the presence of a burdened family history of CVDs, changes in the lipid profile of parents, relatives of the 1st and 2nd lines, and changes in the rigidity of the wall of the great vessels in their children. The rigidity of the vascular wall was significantly higher in Group 1 than in Group 2, differed between children from Group 1a and Group 1b.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2019-epa.101</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Angina ; Aorta ; Arteriosclerosis ; Atherosclerosis ; Blood pressure ; Cardiovascular diseases ; Children ; Childrens health ; Control Groups ; Coronary artery disease ; Dyslipidemia ; Families &amp; family life ; Family (Sociological Unit) ; Genetics ; Health risk assessment ; Heart diseases ; Heredity ; Ischemia ; Pediatrics ; Propagation ; Rigidity ; Statistical analysis ; Wave propagation</subject><ispartof>Archives of disease in childhood, 2019-06, Vol.104 (Suppl 3), p.A43</ispartof><rights>Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2239155445/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2239155445?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21378,21394,27924,27925,33611,33877,43733,43880,74221,74397</link.rule.ids></links><search><creatorcontrib>Slastnikova, Evgeniia</creatorcontrib><creatorcontrib>Sadykova, Dinara</creatorcontrib><creatorcontrib>Leontyeva, Irina</creatorcontrib><creatorcontrib>Galimova, Liliya</creatorcontrib><title>GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases</title><title>Archives of disease in childhood</title><description>Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patients were selected (men ≤55 years, women ≤ 60 years). Their children, grandchildren (144 people) (Group 1) aged 5–17 years were examined. Control group of conditionally healthy children (112 people) was formed (Group 2), their family history was collected with the aim of excluding heredity burdened by CVD. A biochemical blood test was performed to determine the lipid profile; thus, a group with dyslipidemia (Group 1a) was selected among children with burdened family history, which included 76 people (53%), lipidogram indicators (Group 1b) that were normal (68 people, 47%). Rigidity indices of main vessels were determined: PTT (pulse wave propagation time), PWVao (pulse wave propagation speed in the aorta), AIx (augmentation index), (dP/dt) max (max blood pressure rise rate). An ambulatory daily monitor, BPLab® software using Vasotens® technology was used.ResultsIn general, in Group 1, the rigidity indicators of the vascular wall were similar (average daily PTT 145.3 ± 15.9 ms, PWVao 6.7 ± 0.9 m/s, AIx 4.9 ± 8.1%, (dP/dt) max 667.9 ± 119.8 mm Hg/s) with those of Group 2 (average daily PTT 140.5 ± 15.2 ms, PWVao 6.4 ± 1.1 m/s, AIx 5.1 ± 8.2%, (dP/dt) max 668.1 ± 121.3 mm Hg/s) and were statistically significant (p &lt;0.05). However, it was found that if we consider non-maximum daily indicators, then in Group 1 they were significantly higher (p &lt;0.05) (max daily PTT 199.9 ± 10.2 ms, PWVao 16.3 ± 1.4 m/s, AIx 35.3 ± 3.4%, (dP/dt) max 1098.1 ± 120.5 mm Hg/s) than in Group 2 (max daily PTT 181.7 ± 9.6 ms, PWVao 13.1 ± 1.9 m/s, AIx 28.3 ± 1.4%, (dP/dt) max 1005.1 ± 110.3 mm Hg/s). Comparing the parameters between Group 1a and 1b, no statistically significant difference was found between the mean values, but statistically significant difference was found between the maximum values.ConclusionsDirect relationship has been revealed between the presence of a burdened family history of CVDs, changes in the lipid profile of parents, relatives of the 1st and 2nd lines, and changes in the rigidity of the wall of the great vessels in their children. The rigidity of the vascular wall was significantly higher in Group 1 than in Group 2, differed between children from Group 1a and Group 1b.</description><subject>Angina</subject><subject>Aorta</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>Children</subject><subject>Childrens health</subject><subject>Control Groups</subject><subject>Coronary artery disease</subject><subject>Dyslipidemia</subject><subject>Families &amp; family life</subject><subject>Family (Sociological Unit)</subject><subject>Genetics</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Heredity</subject><subject>Ischemia</subject><subject>Pediatrics</subject><subject>Propagation</subject><subject>Rigidity</subject><subject>Statistical analysis</subject><subject>Wave propagation</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNpNkM1KAzEUhYMoWKvvEHE9mkwyM5mlFK1CQUFdh2Ryw6TMT01mLF3pxhf1SUxbFVcXzj2cc--H0Dkll5Sy_Er5qjYuVLVrTJISWiawUpeU0AM0oTwXUeP8EE0IISwphRDH6CSEJSE0FYJN0Pv8kWVfH59Pw2g2uLd4qAGHwVnbQQi_wpsK1dgoj9eqabDr8K7PQ4et71tsVesaBwGv3VBjhfXoDXRgcO3C0PtdbqW8cf1fULwZVIBwio6sagKc_cwperm9eZ7dJYuH-f3sepFomnKaaC6YgKxIqeYMbM5zZQplS10A00LYygptTa7BZjQnXFSWkDwtIOOcl9vfp-hin7vy_esIYZDLfvRdrJRpykqaRWcWXXzv0u1Srrxrld9ISuQWtfyPWm5Ry4g6bin7BlqbeTM</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Slastnikova, Evgeniia</creator><creator>Sadykova, Dinara</creator><creator>Leontyeva, Irina</creator><creator>Galimova, Liliya</creator><general>BMJ Publishing Group LTD</general><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>201906</creationdate><title>GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases</title><author>Slastnikova, Evgeniia ; Sadykova, Dinara ; Leontyeva, Irina ; Galimova, Liliya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1241-b4838e5721b43ef646ad7af9b7e3b88fcf8bfd6bef516048cf00627e544490003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angina</topic><topic>Aorta</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Cardiovascular diseases</topic><topic>Children</topic><topic>Childrens health</topic><topic>Control Groups</topic><topic>Coronary artery disease</topic><topic>Dyslipidemia</topic><topic>Families &amp; family life</topic><topic>Family (Sociological Unit)</topic><topic>Genetics</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Heredity</topic><topic>Ischemia</topic><topic>Pediatrics</topic><topic>Propagation</topic><topic>Rigidity</topic><topic>Statistical analysis</topic><topic>Wave propagation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slastnikova, Evgeniia</creatorcontrib><creatorcontrib>Sadykova, Dinara</creatorcontrib><creatorcontrib>Leontyeva, Irina</creatorcontrib><creatorcontrib>Galimova, Liliya</creatorcontrib><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health &amp; Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Education Journals</collection><collection>ProQuest Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slastnikova, Evgeniia</au><au>Sadykova, Dinara</au><au>Leontyeva, Irina</au><au>Galimova, Liliya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases</atitle><jtitle>Archives of disease in childhood</jtitle><date>2019-06</date><risdate>2019</risdate><volume>104</volume><issue>Suppl 3</issue><spage>A43</spage><pages>A43-</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><abstract>Medical emergency center in Kazan conducted targeted screening to select patients with ischemic strokes, myocardial infarctions, angina pectories, widespread atherosclerosis of peripheral vessels, angiographically confirmed coronary atherosclerosis, ischemic heart disease and dislipidemia. 230 patients were selected (men ≤55 years, women ≤ 60 years). Their children, grandchildren (144 people) (Group 1) aged 5–17 years were examined. Control group of conditionally healthy children (112 people) was formed (Group 2), their family history was collected with the aim of excluding heredity burdened by CVD. A biochemical blood test was performed to determine the lipid profile; thus, a group with dyslipidemia (Group 1a) was selected among children with burdened family history, which included 76 people (53%), lipidogram indicators (Group 1b) that were normal (68 people, 47%). Rigidity indices of main vessels were determined: PTT (pulse wave propagation time), PWVao (pulse wave propagation speed in the aorta), AIx (augmentation index), (dP/dt) max (max blood pressure rise rate). An ambulatory daily monitor, BPLab® software using Vasotens® technology was used.ResultsIn general, in Group 1, the rigidity indicators of the vascular wall were similar (average daily PTT 145.3 ± 15.9 ms, PWVao 6.7 ± 0.9 m/s, AIx 4.9 ± 8.1%, (dP/dt) max 667.9 ± 119.8 mm Hg/s) with those of Group 2 (average daily PTT 140.5 ± 15.2 ms, PWVao 6.4 ± 1.1 m/s, AIx 5.1 ± 8.2%, (dP/dt) max 668.1 ± 121.3 mm Hg/s) and were statistically significant (p &lt;0.05). However, it was found that if we consider non-maximum daily indicators, then in Group 1 they were significantly higher (p &lt;0.05) (max daily PTT 199.9 ± 10.2 ms, PWVao 16.3 ± 1.4 m/s, AIx 35.3 ± 3.4%, (dP/dt) max 1098.1 ± 120.5 mm Hg/s) than in Group 2 (max daily PTT 181.7 ± 9.6 ms, PWVao 13.1 ± 1.9 m/s, AIx 28.3 ± 1.4%, (dP/dt) max 1005.1 ± 110.3 mm Hg/s). Comparing the parameters between Group 1a and 1b, no statistically significant difference was found between the mean values, but statistically significant difference was found between the maximum values.ConclusionsDirect relationship has been revealed between the presence of a burdened family history of CVDs, changes in the lipid profile of parents, relatives of the 1st and 2nd lines, and changes in the rigidity of the wall of the great vessels in their children. The rigidity of the vascular wall was significantly higher in Group 1 than in Group 2, differed between children from Group 1a and Group 1b.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/archdischild-2019-epa.101</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0003-9888
ispartof Archives of disease in childhood, 2019-06, Vol.104 (Suppl 3), p.A43
issn 0003-9888
1468-2044
language eng
recordid cdi_proquest_journals_2239155445
source Social Science Premium Collection; Education Collection
subjects Angina
Aorta
Arteriosclerosis
Atherosclerosis
Blood pressure
Cardiovascular diseases
Children
Childrens health
Control Groups
Coronary artery disease
Dyslipidemia
Families & family life
Family (Sociological Unit)
Genetics
Health risk assessment
Heart diseases
Heredity
Ischemia
Pediatrics
Propagation
Rigidity
Statistical analysis
Wave propagation
title GP35 Study of the stiffness of the vascular wall in children from families with a burdened history of cardiovascular diseases
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T09%3A28%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_bmj_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GP35%E2%80%85Study%20of%20the%20stiffness%20of%20the%20vascular%20wall%20in%20children%20from%20families%20with%20a%20burdened%20history%20of%20cardiovascular%20diseases&rft.jtitle=Archives%20of%20disease%20in%20childhood&rft.au=Slastnikova,%20Evgeniia&rft.date=2019-06&rft.volume=104&rft.issue=Suppl%203&rft.spage=A43&rft.pages=A43-&rft.issn=0003-9888&rft.eissn=1468-2044&rft_id=info:doi/10.1136/archdischild-2019-epa.101&rft_dat=%3Cproquest_bmj_p%3E2239155445%3C/proquest_bmj_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b1241-b4838e5721b43ef646ad7af9b7e3b88fcf8bfd6bef516048cf00627e544490003%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2239155445&rft_id=info:pmid/&rfr_iscdi=true