GP24 Serum renalase levels in adolescents with primary hypertension

BackgroundThe prevalence of hypertension continues to rise in pediatric populations. Recent studies suggest that renalase plays an important role in blood pressure regulation. The aim of this study was to evaluate serum renalase concentrations in hypertensive children.MethodsThis study was a prospec...

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Bibliographic Details
Published in:Archives of disease in childhood 2019-06, Vol.104 (Suppl 3), p.A39
Main Authors: Lemiesz, Marta, Tenderenda-Banasiuk, Edyta, Taranta-Janusz, Katarzyna, Sosnowska, Dorota, Wasilewska, Anna
Format: Article
Language:English
Subjects:
Adolescents
Blood levels
Blood pressure
Childrens health
Cohort Analysis
Enzyme-linked immunosorbent assay
Hypertension
Hyperuricemia
Patients
Pediatrics
Population studies
Reference Groups
Teenagers
Uric acid
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Summary:BackgroundThe prevalence of hypertension continues to rise in pediatric populations. Recent studies suggest that renalase plays an important role in blood pressure regulation. The aim of this study was to evaluate serum renalase concentrations in hypertensive children.MethodsThis study was a prospective cohort analysis of 88 adolescents (40 girls; 48 boys) aged 11 - 18 years, divided into two groups: HT – 38 subjects with primary hypertension and R - reference group – 50 subjects with normal blood pressure. Serum renalase concentration was measured using a commercial enzyme-linked immunosorbent assay kit (USCN Life Science Inc., China).ResultsHypertensive patients had higher serum renalase levels (median 29.8 µg/mL; Q1-Q3: 26.1 – 35.8) than the reference group (median 26.8; Q1-Q3: 22.96 – 29.4, p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2019-epa.91