Interactions between polystyrene nanoparticles and supported lipid bilayers: impact of charge and hydrophobicity modification by specific anions

Understanding how surface forces and aqueous ions influence the interactions between nanoparticles (NPs) and supported lipid bilayers (SLBs) is central to all disciplines interested in studying the nano-bio interface. A prevailing understanding is that cationic NPs have higher penetrating capability...

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Bibliographic Details
Published in:Environmental science. Nano 2019-06, Vol.6 (6), p.1829-1837
Main Authors: Xia, Zehui, Woods, April, Quirk, Amanda, Burgess, Ian J, Lau, Boris L. T
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Analytical methods
Anions
Cations
Cell membranes
Deposition
Hydrophobicity
Infrared absorption
Interactions
Lipid bilayers
Lipids
Membranes
Microbalances
Nanoparticles
Polystyrene
Polystyrene resins
Quartz crystal microbalance
Quartz crystals
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Summary:Understanding how surface forces and aqueous ions influence the interactions between nanoparticles (NPs) and supported lipid bilayers (SLBs) is central to all disciplines interested in studying the nano-bio interface. A prevailing understanding is that cationic NPs have higher penetrating capability across cell membranes. In contrast, we report in this study that anionic polystyrene NPs are capable of binding and penetrating SLBs formed by zwitterionic DOPC when charge and hydrophobicity work in concert with specific anions. The preferential deposition of anionic NPs onto the bilayer is rationalized electrostatically by considering the slightly positive charge of DOPC. In addition to charge, NP hydrophobicity played an important role in the subsequent penetration of anionic NPs into SLBs. The extent of NP deposition was modulated by chaotropic anions (NO 3 − ). This study also demonstrates the promise of using a novel combination of surface sensitive techniques, quartz crystal microbalance with dissipation monitoring (QCM-D) and surface-enhanced infrared absorption spectroscopy (SEIRAS), to extend the current understanding of NP-SLB interactions to the molecular scale. The interaction between nanoparticles and zwitterionic supported lipid bilayers is a multi-step process, with specific ions exerting their influences on electrostatic-driven NP deposition and hydrophobicity-induced membrane disruption.
ISSN:2051-8153
2051-8161
DOI:10.1039/c9en00055k