Synthesis and halocyclization of 2-mercaptonicotinic acid propargyl derivatives

Alkylation of 2-sulfanylpyridine-3-carboxylic acid with 3-bromo-1-propyne proceeds with the formation of 2-(prop-2-yn-1-ylsulfanyl)-pyridine-3-carboxylic acid and prop-2-yn-1-yl 2-(prop-2-yn-1-ylsulfanyl)pyridine-3-carboxylate, which react with bromine and iodine to form 2,3-dihydro[1,3]thiazolo[3,2...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-05, Vol.55 (4-5), p.473-477
Main Authors: Kalita, Elena V., Kim, Dmitry G., Eltsov, Oleg S., Shtukina, Taisiya S., Mukhametgaleeva, Irina V.
Format: Article
Language:English
Subjects:
Alkylation
Bromine
Chemistry
Chemistry and Materials Science
College presidents
Enzymes
Iodine
Organic Chemistry
Oxidation-reduction reactions
Pharmacy
Physiological aspects
Pyridine
Vitamins
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Summary:Alkylation of 2-sulfanylpyridine-3-carboxylic acid with 3-bromo-1-propyne proceeds with the formation of 2-(prop-2-yn-1-ylsulfanyl)-pyridine-3-carboxylic acid and prop-2-yn-1-yl 2-(prop-2-yn-1-ylsulfanyl)pyridine-3-carboxylate, which react with bromine and iodine to form 2,3-dihydro[1,3]thiazolo[3,2- a ]pyridinium systems.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02483-9