Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

Ketoconazole (KTZ) was incorporated in waterborne poly(urethane-urea)s dispersions (WPUU), aiming at the production of films for drug sustained release. Dispersions based on poly(ethylene glycol- -propylene glycol) (PEG- -PPG) (four monomers with different contents of PEG hydrophilic segments), poly...

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Bibliographic Details
Published in:e-Polymers 2019-01, Vol.19 (1), p.168-180
Main Authors: Vieira, Italo Rennan Sousa, Miranda, Gisele dos Santos, Ricci-Júnior, Eduardo, Delpech, Marcia Cerqueira
Format: Article
Language:English
Subjects:
block polyether-based copolymers
Computer simulation
Diisocyanates
Dispersions
drug delivery systems
Erosion
Ethylene glycol
Fourier transforms
Hydrazines
Infrared spectroscopy
ketoconazole
kinetic profile
Linear equations
Materials science
Polymers
Propylene
Pseudoplasticity
Segments
Sustained release
Ureas
waterborne poly(urethane-urea)s
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Summary:Ketoconazole (KTZ) was incorporated in waterborne poly(urethane-urea)s dispersions (WPUU), aiming at the production of films for drug sustained release. Dispersions based on poly(ethylene glycol- -propylene glycol) (PEG- -PPG) (four monomers with different contents of PEG hydrophilic segments), poly(propylene glycol), isophorone diisocyanate, dime-thylolpropionic acid and hydrazine were produced and characterized by apparent viscosity and average particle size (APS). Cast films-drug interaction was investigated by Fourier-Transform infrared spectrometry (FTIR). dissolution assays were performed in simulated gastrointestinal juices, followed by application of kinetic models. Stable pseudoplastic dispersions, with APS between 27 to 320 nm were obtained. FTIR from KTZ-loaded films indicated interactions between polymer and drug. release of KTZ was achieved above 80%, notably influenced by PEG-based segments content up to 2 h, followed by sustained release for 8 h. Higuchi’s and first-order equations described the drug kinetic profile, as diffusion of the drug and erosion of the swollen polymer, respectively.
ISSN:2197-4586
1618-7229
DOI:10.1515/epoly-2019-0018