Copper-catalyzed Cyanation of Aryl Iodides Using Nitromethane

The copper-catalyzed cyanation of aryl iodides is described using nitromethane as a CN source. In situ generation of a “CN” species from nitromethane is plausible. This strategy is an advantageous synthetic method for the construction of an aromatic C–CN bond, because nitromethane is a common and ea...

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Bibliographic Details
Published in:Chemistry letters 2017-12, Vol.46 (12), p.1736-1739
Main Authors: Ogiwara, Yohei, Morishita, Hiromitsu, Sasaki, Minoru, Imai, Hiroki, Sakai, Norio
Format: Article
Language:English
Subjects:
Aromatic compounds
Copper
Cyanides
Iodides
Nitromethane
Reagents
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Summary:The copper-catalyzed cyanation of aryl iodides is described using nitromethane as a CN source. In situ generation of a “CN” species from nitromethane is plausible. This strategy is an advantageous synthetic method for the construction of an aromatic C–CN bond, because nitromethane is a common and easily handled compound that is readily available as a cyanation reagent, and its use allows the avoidance of using toxic metal cyanides.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.170798