Fluorescence detection of glutathione S-transferases in a low GSH level environment

Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes, we developed a fluorescent probe enabling the detection of intracellular GSTs in a...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-06, Vol.55 (5), p.7219-7222
Main Authors: Song, Aiguo, Feng, Tian, Shen, Xin, Gai, Shouchang, Zhai, Yumeng, Chen, Hui
Format: Article
Language:English
Subjects:
Fluorescent indicators
Glutathione
Pretreatment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes, we developed a fluorescent probe enabling the detection of intracellular GSTs in a low GSH level environment by pre-treatment of the cells with thiol-scavengers. Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc02702e