Multi walled carbon nanotubes supported CuO-Au hybrid nanocomposite for the effective application towards the electrochemical determination of Acetaminophen and 4-Aminophenol

• Published in: Synthetic metals 2019-06, Vol.252, p.29-39
• Main Authors: Shaikshavali, P., Madhusudana Reddy, T., Palakollu, V.N., Karpoormath, R., Subba Rao, Y., Venkataprasad, G., Gopal, T. Venu, Gopal, P.
• Format: Article
• Language: English
• Subjects: 4-Aminophenol; Acetaminophen; Aminophenol; Analgesics; Carbon; Chemical sensors; CuO-Au nanocomposite; Dispersion; Field emission microscopy; Fourier transforms; Glassy carbon; Gold; Infrared spectroscopy; Multi wall carbon nanotubes; Multiwalled; Nanocomposites; Nanotubes; Scanning electron microscopy; Sensors; Voltammetry
• ISSN: 0379-6779; 1879-3290
• DOI: 10.1016/j.synthmet.2019.04.009

[Display omitted] •CuO-Au/MWCNTs/GCE was effectively used for the determination of AC and 4-AP.•CuO-Au/MWCNTs characterized by using FT-IR, FE-SEM, CV and EIS analysis.•The fabricated nanocomposite sensor showed good sensitivity and low LOD.•The kinetic parameters of the electrode process were investigated.•CuO-Au/MWCNTs was used for the sensing AC in pharmaceutical and human serum sample. Herein, a newly developed CuO-Au composite was successfully decorated on multiwalled carbon nanotubes (MWCNTs) and employed as an electrochemical sensor. The developed nanocomposite (CuO-Au/MWCNTs) was dispersed on the surface of glassy carbon electrode (GCE) to produce CuO-Au/MWCNTs/GCE. The characterizations of nanocomposite was examined with the help of field emission scanning electron microscopy (FE-SEM), energy dispersive x-ray spectrometry (EDX) and fourier transform infrared spectroscopy (FT-IR) techniques. The sensor showed promising electrocatalytic activity towards the individual and simultaneous determination of Acetaminophen (AC) and 4-Aminophenol (4-AP). The sensor showed good linear response for AC and 4-AP in the range from 0.2 μM to 6.0 μM and 0.5 μM to 1.6 μM with detection limits of 0.016 μM and 0.105 μM respectively. The sensor showed potential applications in evaluating kinetic parameters. The practical application of the developed electrochemical sensor was verified in pharmaceutical formulation and human serum sample successfully.