Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301

Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6–19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from th...

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Bibliographic Details
Published in:Fitoterapia 2019-06, Vol.135, p.27-32
Main Authors: Liu, Nianzhen, Peng, Shuai, Yang, Jie, Cong, Ziwen, Lin, Xiuping, Liao, Shengrong, Yang, Bin, Zhou, Xuefeng, Zhou, Xiaojiang, Liu, Yonghong, Wang, Junfeng
Format: Article
Language:English
Subjects:
Antiviral activity
Aspergillus sydowii
Circular dichroism
Cytotoxicity
Dichroism
Fungi
Influenza A
Polyketides
Sesquiterpenoid
Sesquiterpenoids
Viruses
Xanthone
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Summary:Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6–19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1–3, and 6–19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC50 values ranging from 2.17 ± 1.39 to 4.70 ± 1.11 μM. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.03.031