Antimicrobial and anti-biofilm properties of novel synthetic lignan-like compounds

Antibiotic resistance and biofilm tolerance are among the principal factors involved in the persistence of chronic infections. The need for new antimicrobials is an ever-increasing challenge in clinical environments and in the control of global health. Arylfurans form a set of structures that have b...

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Bibliographic Details
Published in:The New microbiologica 2019-01, Vol.42 (1), p.21
Main Authors: Vollaro, Adriana, Catania, Maria R, Iesce, Maria R, Sferruzza, Rosalia, D'Abrosca, Brigida, Donnarumma, Giovanna, De Filippis, Anna, Cermola, Flavio, DellaGreca, Marina, Buommino, Elisabetta
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Biofilms
Confocal microscopy
Cytotoxicity
Drug resistance
E coli
Fungi
Global health
Infections
Lignans
Methicillin
Microscopy
Minimum inhibitory concentration
Natural products
Polyphenols
Pseudomonas aeruginosa
Scanning microscopy
Staphylococcus epidermidis
Viability
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Summary:Antibiotic resistance and biofilm tolerance are among the principal factors involved in the persistence of chronic infections. The need for new antimicrobials is an ever-increasing challenge in clinical environments and in the control of global health. Arylfurans form a set of structures that have been identified in many natural products, e.g. lignans. Lignans are a sub-group of non-flavonoid polyphenols that play an active role in plants' defense against bacteria and fungi infections. The aim of this study was to identify novel synthetic arylfurans and lignan-like arylbenzylfurans exhibiting antimicrobial properties. The molecules synthetized were tested against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and S. epidermidis. We found that among tested compounds, arylbenzylfuran 11 was active against S. aureus and S. epidermidis with an MIC of 4 μg ml-1. Compound 11 was also active on methicillin-resistant S. aureus and S. epidermidis. By confocal laser scanning microscopy, we showed that 32 μg ml-1 of compound 11 was able to induce a significant reduction in S. aureus and S. epidermidis biofilms viability. Finally, we demonstrated that compound 11 was not cytotoxic on HaCat cells up to 128 μg ml-1. This work shows the antimicrobial and anti-biofilm potential of a synthetic lignan-like furan.
ISSN:1121-7138