Midazolam prevents sevoflurane-induced death in hippocampal neurons

•Sevoflurane inhibited viability induced hippocampal neuronal death.•Midazolam treatment prevented hippocampal neuronal death exposed to sevoflurane and promoted neuronal maturation.•Midazolam alleviated memory deficit in mouse exposed to sevoflurane.•The effect of midazolam on sevoflurane-exposed h...

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Bibliographic Details
Published in:Tissue & cell 2019-06, Vol.58, p.1-7
Main Authors: Yu, Dongnan, Zhu, Yi, Cui, Can, Long, Ruichun, Ma, Jue
Format: Article
Language:English
Subjects:
Anesthetics
Animal behavior
Apoptosis
Central nervous system
Death
Exposure
Hippocampal neuron
Hippocampus
In vivo methods and tests
Midazolam
Mortality
Neurons
Neuroprotection
Neurotoxicity
Reagents
Sevoflurane
Surgery
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Summary:•Sevoflurane inhibited viability induced hippocampal neuronal death.•Midazolam treatment prevented hippocampal neuronal death exposed to sevoflurane and promoted neuronal maturation.•Midazolam alleviated memory deficit in mouse exposed to sevoflurane.•The effect of midazolam on sevoflurane-exposed hippocampal neurons was mediate by ERK signaling. Sevoflurane is a widely used anesthetics in surgery and considered as a safe reagent for clinical use. However, recent studies demonstrated that sevoflurane has a neurotoxic effect in central nervous system. Thus, finding ways to alleviate the side effect of sevoflurane is of importance. In this study, we identified the neuroprotective role of midazolam in hippocampal neurons. Midazolam treatment could alleviate the neuronal death and promote the neuronal maturation in hippocampal neurons in vitro. In vivo studies demonstrated that midazolam injection could improve behavioral deficit in sevoflurane-exposed animals. The anti-apoptotic function of midazolam in sevoflurane-exposed neurons was mediated by ERK signaling. Collectively, we elucidated a new role of midazolam in preventing hippocampal neuronal death from sevoflurane exposure, potentially providing a new strategy to resist the neurotoxicity in the clinical application of sevoflurane.
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2019.03.001