Reductions in levels of bacterial superantigens/cannabinoids by plasma exchange in a patient with severe toxic shock syndrome

Toxic shock syndrome is a rare but potentially fatal toxin-mediated febrile illness. We report a case of toxic shock syndrome complicated by life-threatening organ dysfunction with high toxin-1 and staphylococcus enterotoxin type A levels that were successfully reduced by early introduction of plasm...

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Bibliographic Details
Published in:Anaesthesia and intensive care 2004-08, Vol.32 (4), p.588-591
Main Authors: KOHRO, S, IMAIZUMI, H, YAMAKAGE, M, MASUDA, Y, NAMIKI, A, ASAI, Y
Format: Article
Language:English
Subjects:
Adolescent
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Arachidonic Acids - blood
Bacterial Toxins - blood
Biological and medical sciences
Cannabinoid Receptor Modulators - blood
Diglycerides - blood
Endocannabinoids
Enterotoxins - blood
Humans
Male
Medical sciences
Plasma Exchange
Polyunsaturated Alkamides
Shock, Septic - blood
Shock, Septic - microbiology
Shock, Septic - therapy
Staphylococcal Infections - blood
Staphylococcal Infections - therapy
Staphylococcus aureus - immunology
Superantigens - blood
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Summary:Toxic shock syndrome is a rare but potentially fatal toxin-mediated febrile illness. We report a case of toxic shock syndrome complicated by life-threatening organ dysfunction with high toxin-1 and staphylococcus enterotoxin type A levels that were successfully reduced by early introduction of plasma exchanges. The report shows the time course of the concentrations of anandamide and 2-arachidonyl glyceride and confirms that early introduction of plasma exchange can result in a rapid reduction of circulating toxins and mediators in the treatment of life-threatening multiple organ dysfunction.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057x0403200420